869279-02-7

Upstream product

• 75-15-0 carbon disulfide 
• 1978-39-8 5-fluoro-2-methoxy-aniline 
• 445-83-0 4-fluoro-1-methoxy-2-nitrobenzene 

Downstream Products

• 869278-97-7 O-isopropyl 5-fluoro-2-methoxyphenylthiocarbamate 
• 1415135-04-4 N-(5-fluoro-2-methoxyphenyl)thiourea 
• 1415233-57-6 (5-Fluoro-2-methoxy-phenyl)-[4-(1-methyl-1H-benzoimidazol-5-yl)-thiazol-2-yl]-amine 
• 1415233-58-7 (5-Fluoro-2-methoxy-phenyl)-[4-(2,3,5-trimethyl-3H-imidazol-4-yl)-thiazol-2-yl]-amine 

Relevant academic research and scientific papers

PHENYL-THIAZOLYL INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION

This invention relates to phenyl thiazole I and its therapeutic and prophylactic uses, wherein the variables Rz, Q, J, R1, R3, R5, R6, and R7 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.

METHODS OF INHIBITING PRO MATRIX METALLOPROTEINASE ACTIVATION

This invention relates to methods for preventing, treating or ameliorating an MMP9 and/or MMP13 mediated syndrome, disorder or disease comprising administering to a subject in need thereof an effective amount of a compound listed in the examples section of this specification, or a form, composition or medicament thereof. Disorders treated and/or prevented include rheumatoid arthritis.

Synthesis of the marine sponge derived β2-adrenoceptor agonist S1319

(Chemical Equation Presented) The marine sponge derived β2-adrenoceptor agonist S1319 has been synthesized following a six-step linear sequence. Central to the approach employed is the formation of a 7-lithiated-2,4-dialkoxybenzothiazole interm