7033-51-4

Usage

Uses

Used in Organic Synthesis:
6-CHLORO-2-PHENYLBENZO[D][1,3]OXAZIN-4-ONE is used as a building block in the synthesis of other organic compounds, leveraging its unique structure to create a variety of complex molecules for different applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 6-CHLORO-2-PHENYLBENZO[D][1,3]OXAZIN-4-ONE is used as a starting material for the development of pharmaceuticals. Its potential therapeutic applications are being explored, with the aim of discovering new drugs that can benefit from its chemical properties.
Further research and exploration of 6-CHLORO-2-PHENYLBENZO[D][1,3]OXAZIN-4-ONE's chemical and biological properties are necessary to fully understand and harness its potential uses and applications across various industries.

Upstream product

• 98-88-4 benzoyl chloride 
• 635-21-2 5-chloroanthranilic acid 
• 112182-50-0 6-chloro-2-phenylquinolin-4(1H)-one 
• 1663-61-2 triethoxymethylbenzene 
• 13421-00-6 5-chloro-2-iodo-benzoic acid 
• 100-47-0 benzonitrile 
• 63069-48-7 p-chloro-o-iodoaniline 
• 1864-94-4 phenyl formate 
• 17630-76-1 5-chloroindole 2,3-dione 
• 611-73-4 Benzoylformic acid 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 495-18-1 Benzohydroxamic acid 
• 591-50-4 iodobenzene 
• 201230-82-2 carbon monoxide 

Downstream Products

• 869365-84-4 N-[4-chloro-2-(2-methyl-benzoyl)-phenyl]-benzamide 
• 869365-88-8 N-[4-Chloro-2-(2-fluoro-6-methoxy-benzoyl)-phenyl]-benzamide 
• 1256947-87-1 C₂₁H₁₅ClN₄O₂ 
• 1256947-92-8 C₂₁H₁₃ClN₄O 
• 1402939-28-9 6-chloro-3-(4-methylphenyl)-2-phenylquinazolin-4(3H)-one 
• 7012-93-3 6-chloro-2,3-diphenylquinazolin-4(3H)-one 
• 39860-60-1 4-chloro-2-(2'-thienylcarbonyl)-N-bromoacetylaniline 
• 91805-28-6 4-chloro-2-(2'-furoyl)-N-bromoacetylaniline 
• 60514-58-1 (2-amino-5-chlorophenyl)(2-furyl)methanone 
• 41631-21-4 2-amino-5-chlorophenyl 2-thienyl ketone 
• 170301-13-0 4-chloro-2-(2'-furoyl)-N-benzoylaniline 
• 170301-12-9 4-chloro-2-(2'-thienylcarbonyl)-N-benzoylaniline 
• 21259-25-6 N-Benzoyl-2-amino-5-chlorobenzophenone 

Relevant academic research and scientific papers

Direct synthesis of benzoxazinones via Cp*Co(III)-catalyzed C–H activation and annulation of sulfoxonium ylides with dioxazolones

A highly novel and direct synthesis of benzoxazinones was developed via Cp*Co(III)-catalyzed C–H activation and [3 + 3] annulation between sulfoxonium ylides and dioxazolones. The reaction is conducted under base-free conditions and tolerates various functional groups. Starting from diverse readily available sulfoxonium ylides and dioxazolones, a variety of benzoxazinones could be synthesized in one step in 32%-75% yields.

One pot synthesis of some new N-allyl and N-benzyl quinazolinones and their anti-inflammatory activity

The simple and more reliable one-pot synthesis of some novel compounds of allyl/Benzyl quinazolinone (4aa-4bd) with good yields from readily available derivatives of anthranilic acid and benzoyl chloride was also reported. Interestingly, as compared to Di

Recyclable Heterogeneous Palladium-Catalyzed Carbonylative Cyclization of 2-Iodoanilines with Aryl Iodides Leading to 2-Arylbenzoxazinones

A highly efficient and practical heterogeneous palladium-catalyzed carbonylative coupling of 2-iodoanilines with aryl iodides has been developed. The reaction occurs smoothly in toluene at 110 °C with N, N -diisopropylethylamine as base under carbon monoxide (5 bar) and offers a general and powerful tool for the construction of various valuable 2-arylbenzoxazinones with excellent atom-economy, high functional group tolerance, good to high yields, and easy recyclability of the palladium catalyst. The reaction is the first example of heterogeneous palladium-catalyzed carbonylative coupling for the preparation of diverse 2-arylbenzoxazinones from commercially easily available 2-iodoanilines and aryl iodides.

From Methaqualone and Beyond: Structure - Activity Relationship of 6-, 7-, and 8-Substituted 2,3-Diphenyl-quinazolin-4(3H)-ones and in Silico Prediction of Putative Binding Modes of Quinazolin-4(3H)-ones as Positive Allosteric Modulators of GABAA

Methaqualone (2-methyl-3-(o-tolyl)-quinazolin-4(3H)-one, MTQ) is a moderately potent positive allosteric modulator (PAM) of GABAA receptors (GABAARs). In a previous structure-activity relationship (SAR) study probing the importance of 2- and 3-substituent

Palladium (0)-catalyzed C(sp2)-H oxygenation with carboxylic acids

Palladium (0)-catalyzed Ortho-benzoxylation of the sp2 C–H bond of arylbenzoxazinones with carboxylic acid is reported. With benzoxazinone as directing group, the reaction went smoothly under the benign condition and gave the desired product wi

Benzoxazinone compound of the horticultural fungicide (by machine translation)

[Problem] in the production of agricultural and horticultural crops, new horticultural fungicide containing the same. The present invention is [solution] horticultural fungicide containing, equation (1) (1)[In the formula, The R, a hydrogen atom, a haloge

One-Pot Synthesis of 2-Arylbenzoxazinones from 2-Arylindoles with (Diacetoxyiodo)benzene as the Sole Oxidant

A series of synthetically interesting 2-arylbenzoxazinones was prepared from 2-arylindoles by an efficient oxidative reaction mediated by (diacetoxyiodo)benzene [PhI(OAc) 2 ] and assisted by water. PhI(OAc) 2 was used as the sole oxi

Design, synthesis and pharmacological evaluation of 2-phenyl quinazolin-4-one derivatives as anticolorectal cancer and anti-inflammatory agent

Quinazoline derivatives are heterocyclic compounds that acts as important structural lead for the discovery of effective therapeutic agents. The anti-inflammatory activity along with cytotoxicity helps to reduce the inflammation and pain associated with carcinoma. Derivatives of quinazoline-4-one were preliminary screened and in silico molecular modelling studies using Autodock were performed. In the docking study, ligands were docked against anticancer and anti-inflammatory targets. In silico analysis revealed that the compounds with aromatic substitution at 3rd and halogen substitution at 6th or 7th positions possess lesser side effects and have more potent antitumor activity. Based upon these results 12 compounds were selected, synthesized, characterized and screened for their in vitro, anti-inflammatory, antioxidant and anticancer activities. From the in vitro studies, compounds QA4, QA7 and QB1 showed good anticancer, anti-inflammatory and antioxidant activity when compared to the standard.

Mechanochemical Synthesis of Substituted 4H-3,1-Benzoxazin-4-ones, 2-Aminobenzoxazin-4-ones, and 2-Amino-4H-3,1-benzothiazin-4-ones Mediated by 2,4,6-Trichloro-1,3,5-triazine and Triphenylphosphine

A mild and convenient approach for the synthesis of 2-substituted 4H-3,1-benzoxazin-4-ones, 2-aminobenzoxazin-4-ones, and 2-amino-4H-3,1-benzothiazin-4-ones under solvent-assisted grinding is reported. In the presence of 2,4,6-trichloro-1,3,5-triazine and

Copper-Catalyzed C–N, C–O Coupling Reaction of Arylglyoxylic Acids with Isatins

The copper(II)-catalyzed decarboxylative coupling reactions of arylglyoxylic acids with isatins afford 4H-benzo[d][1,3]oxazin-4-ones via decarbonylation and concurrent C–N, C–O bond formation. (Figure presented.).