869725-56-4 Usage
Uses
Used in Organic Synthesis:
2-bromo-5-(trifluoromethyl)-benzenepropanoic acid serves as a key building block in the synthesis of various organic compounds. Its presence of a bromine atom and a trifluoromethyl group on the benzene ring allows for a range of chemical reactions, making it a valuable intermediate in the creation of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2-bromo-5-(trifluoromethyl)-benzenepropanoic acid is utilized as a precursor in the development of new drugs. Its unique structure and reactivity contribute to the design of pharmaceutical compounds with specific therapeutic properties, potentially leading to the discovery of novel treatments for various diseases.
Used in Chemical Research:
2-bromo-5-(trifluoromethyl)-benzenepropanoic acid is also employed in chemical research to study the effects of bromine and trifluoromethyl substitutions on the reactivity and stability of benzene derivatives. This research can provide insights into the development of new synthetic methods and the understanding of reaction mechanisms in organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 869725-56-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,9,7,2 and 5 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 869725-56:
(8*8)+(7*6)+(6*9)+(5*7)+(4*2)+(3*5)+(2*5)+(1*6)=234
234 % 10 = 4
So 869725-56-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H8BrF3O2/c11-8-3-2-7(10(12,13)14)5-6(8)1-4-9(15)16/h2-3,5H,1,4H2,(H,15,16)
869725-56-4Relevant academic research and scientific papers
Discovery of INCB9471, a potent, selective, and orally bioavailable CCR5 antagonist with potent anti-HIV-1 activity
Xue, Chu-Biao,Chen, Lihua,Cao, Ganfeng,Zhang, Ke,Wang, Anlai,Meloni, David,Glenn, Joseph,Anand, Rajan,Xia, Michael,Kong, Ling,Huang, Taisheng,Feng, Hao,Zheng, Changsheng,Li, Mei,Galya, Laurine,Zhou, Jiacheng,Shin, Niu,Baribaud, Fredric,Solomon, Kim,Scherle, Peggy,Zhao, Bitao,Diamond, Sharon,Emm, Tom,Keller, Douglas,Contel, Nancy,Yeleswaram, Swamy,Vaddi, Kris,Hollis, Gregory,Newton, Robert,Friedman, Steven,Metcalf, Brian
scheme or table, p. 483 - 487 (2011/03/20)
To identify a CCR5 antagonist as an HIV-1 entry inhibitor, we designed a novel series of indane derivatives based on conformational considerations. Modification on the indane ring led to the discovery of compound 22a (INCB9471) that exhibited high affinit
Piperazinylpiperidine derivatives as chemokine receptor antagonists
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Page/Page column 25, (2008/06/13)
The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR
