869938-32-9

Upstream product

• 305837-95-0 4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide 
• 513-42-8 3-hydroxy-2-methyl-1-propene 
• 18303-04-3 N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide 
• 591-50-4 iodobenzene 
• 55022-46-3 4-methyl-N-prop-2-ynylbenzenesulfonamide 
• 920-46-7 Methacryloyl chloride 
• 98-59-9 p-toluenesulfonyl chloride 
• 563-47-3 3-Chloro-2-methylpropene 
• 189031-66-1 N-(tert-butoxycarbonyl)-4-methyl-N-prop-2-ynylbenzenesulfonamide 
• 1206-41-3 N-(2-methylallyl)-4-toluenesulfonamide 
• 1794-48-5 1-bromo-3-phenylprop-2-yne 
• 70-55-3 toluene-4-sulfonamide 
• 1458-98-6 2-methyl-3-bromo-1-propene 
• 132330-45-1 4-methyl-N-(2-methylallyl)-N-(prop-2-ynyl)benzenesulfonamide 

Downstream Products

• 1152172-68-3 1-methyl-6-phenyl-3-(p-toluenesulfonyl)-3-aza-bicyclo[4.1.0]hept-4-ene 
• 1242176-33-5 3a-methyl-6-phenyl-2-tosyl-2,3,3a,4-tetrahydrocyclopenta[c]pyrrol-5(1H)-one 
• 1260522-66-4 4-methyl-N-((2-methyloxiran-2-yl)methyl)-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide 
• 1260522-67-5 (E)-(4-benzylidene-3-methyl-1-tosylpyrrolidin-3-yl)methanol 
• 1342795-43-0 (Z)-4-benzylidene-3,3-dimethyl-1-tosylpyrrolidine 
• 1598431-55-0 (5-methyl-1-tosyl-3,4-dehydropiperidin-3-yl)(phenyl)methanone 

Relevant academic research and scientific papers

Alkene: Versus alkyne reactivity in unactivated 1,6-enynes: Regio-And chemoselective radical cyclization with chalcogens under metal-And oxidant-free conditions

Herein, we have developed metal and oxidant-free visible light-promoted alkene vs. alkyne regio-And chemoselective radical cascade cyclization of electronically unbiased 1,6-enynes with chalcogens to synthesize substituted pyrrolidines bearing chalcogens. The reaction generated three new bonds, namely, C-SO2, C-C, and C-Se under extremely mild conditions. Furthermore, we achieved regio-And chemoselective mono-addition of aromatic thiophenols with unactivated 1,6-enynes. The key features of this protocol are broad substrate scope, environment-friendly conditions, operational simplicity, atom economy, and amenability to gram-scale synthesis. The mechanistic studies corroborate that the reaction proceeds via a radical pathway.

Synthesis of Chlorotrifluoromethylated Pyrrolidines by Electrocatalytic Radical Ene-Yne Cyclization

The stereoselective synthesis of chlorotrifluoromethylated pyrrolidines was achieved using anodically coupled electrolysis, an electrochemical process that combines two parallel oxidative events in a convergent and productive manner. The bench-stable and

Benzimidazolium- and Benzimidazolilydene-Capped Cyclodextrins: New Perspectives in Anion Encapsulation and Gold-Catalyzed Cycloisomerization of 1,6-Enynes

A new way of introducing a N-heterocyclic carbene cap onto cyclodextrins has been devised. The benzimidazolium intermediates were found to behave as receptors towards cavity matching anions. The corresponding C1- and C2-symmetrical r

Copper-Catalyzed [2 + 2 + 3] Annulation of 1,6-Enynes with α-Bromo-1,3-Dicarbonyl Compounds: Synthesis of Dihydrooxepines

Copper-catalyzed [2 + 2 + 3] annulation of 1,6-enynes with α-bromo-1,3-dicarbonyl compounds is described. This reaction provides facile access to seven-membered dihydrooxepines for epidithiodiketopiperazines with two newly formed C-C bonds and one C-O bon

Palladium-catalyzed oxidative 6-exo-trig cyclization of 1,6-enynes: Facile synthesis of bicyclo[4.1.0]heptan-5-ones

We here describe a new palladium-catalyzed oxidative 6-exo-trig cyclization of 1,6-enynes at room temperature using tBuONO as an oxidant for the synthesis of 3-bicyclo[4.1.0]heptan-5-ones. This cascade strategy involves the hydration, cyclization and cycl

Palladium-Catalyzed Radical Cascade Iododifluoromethylation/Cyclization of 1,6-Enynes with Ethyl Difluoroiodoacetate

A novel and convenient Pd-catalyzed radical cascade iododifluoromethylation/cyclization of 1,6-enynes with ethyl difluoroiodoacetate is demonstrated. The proposed transformation presents high stereoselectivity under mild and facile reaction conditions, th

Copper-Catalyzed Cascade Cyclization for the Synthesis of Trifluoromethyl-Substituted Spiro-2H-azirines from 1,6-Enynes

A method for the synthesis of trifluoromethyl CF3-substituted spirocyclic compounds containing with a unique quaternary carbon center from readily available starting materials has been developed. The reaction provides a facile access to 2H-azir

Copper-catalyzed three-component cyanotrifluoromethylation/ azidotrifluoromethylation and carbocyclization of 1,6-enynes

A novel three-component strategy for the cyanotrifluoromethylation/ azidotrifluoromethylation and carbocyclization of 1,6-enynes is developed. The reaction proceeds smoothly under a moderate temperature by using a copper catalyst, which provides a rapid a

Lewis acid mediated intramolecular C-C bond formation of alkyne-epoxide leading to six-membered nitrogen and oxygen heterocycles

Intramolecular C-C bond formation of oxygen- and nitrogen-tethered alkynes and epoxide mediated by Lewis acid under ambient conditions is described. A simple procedure for the synthesis of 3,6- and 5,6-dihydropyrans and 3,4-dehydropiperidines from acyclic

Copper-catalyzed trifluoromethylation-cyclization of enynes: Highly regioselective construction of trifluoromethylated carbocycles and heterocycles

Regioselective trifluoromethylation-cyclization: A method for copper-catalyzed trifluoromethylation-cyclization of simple enynes using the C-C triple bond as a nucleophile is reported for the first time (see scheme). The reaction proceeds efficiently in a