870544-59-5 Usage
Uses
Used in Pharmaceutical Industry:
Urea, N-[2-[2-(1,1-dimethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoromethoxy)phenyl]is used as a non-nucleotide antagonist of the P2Y1 receptor for its ability to block nerve-mediated inhibitory neuromuscular responses in the gastrointestinal tract of rodents. This makes it a promising candidate for the development of drugs targeting gastrointestinal disorders and related conditions.
Used in Research Applications:
Due to its unique structure and biological properties, Urea, N-[2-[2-(1,1-dimethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoromethoxy)phenyl]can be used as a research tool in various scientific studies. It can help researchers gain insights into the mechanisms of action of P2Y1 receptor antagonists and their potential therapeutic applications.
Used in Drug Discovery:
Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]-'s ability to modulate the P2Y1 receptor makes it a valuable starting point for drug discovery efforts. Researchers can use Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- as a lead molecule to develop new drugs with improved efficacy and safety profiles for the treatment of gastrointestinal and other related disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 870544-59-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,0,5,4 and 4 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 870544-59:
(8*8)+(7*7)+(6*0)+(5*5)+(4*4)+(3*4)+(2*5)+(1*9)=185
185 % 10 = 5
So 870544-59-5 is a valid CAS Registry Number.
870544-59-5Relevant academic research and scientific papers
Studies towards the development of a PET radiotracer for imaging of the P2Y1 receptors in the brain: synthesis, 18F-labeling and preliminary biological evaluation
Moldovan, Rare?-Petru,Wenzel, Barbara,Teodoro, Rodrigo,Neumann, Wilma,Dukic-Stefanovic, Sladjana,Kraus, Werner,Rong, Peijing,Deuther-Conrad, Winnie,Hey-Hawkins, Evamarie,Krügel, Ute,Brust, Peter
, p. 142 - 159 (2019/01/23)
Purine nucleotides such as ATP and ADP are important extracellular signaling molecules in almost all tissues activating various subtypes of purinoreceptors. In the brain, the P2Y1 receptor (P2Y1R) subtype mediates trophic functions l
Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y 1 antagonists
Chao, Hannguang,Turdi, Huji,Herpin, Timothy F.,Roberge, Jacques Y.,Liu, Yalei,Schnur, Dora M.,Poss, Michael A.,Rehfuss, Robert,Hua, Ji,Wu, Qimin,Price, Laura A.,Abell, Lynn M.,Schumacher, William A.,Bostwick, Jeffrey S.,Steinbacher, Thomas E.,Stewart, Anne B.,Ogletree, Martin L.,Huang, Christine S.,Chang, Ming,Cacace, Angela M.,Arcuri, Maredith J.,Celani, Deborah,Wexler, Ruth R.,Lawrence, R. Michael
, p. 1704 - 1714 (2013/04/10)
Two distinct G protein-coupled purinergic receptors, P2Y1 and P2Y12, mediate ADP-driven platelet activation. The clinical effectiveness of P2Y12 blockade is well established. Recent preclinical data suggest that P2Y1
