870544-79-9Relevant academic research and scientific papers
Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y 1 antagonists
Chao, Hannguang,Turdi, Huji,Herpin, Timothy F.,Roberge, Jacques Y.,Liu, Yalei,Schnur, Dora M.,Poss, Michael A.,Rehfuss, Robert,Hua, Ji,Wu, Qimin,Price, Laura A.,Abell, Lynn M.,Schumacher, William A.,Bostwick, Jeffrey S.,Steinbacher, Thomas E.,Stewart, Anne B.,Ogletree, Martin L.,Huang, Christine S.,Chang, Ming,Cacace, Angela M.,Arcuri, Maredith J.,Celani, Deborah,Wexler, Ruth R.,Lawrence, R. Michael
, p. 1704 - 1714 (2013/04/10)
Two distinct G protein-coupled purinergic receptors, P2Y1 and P2Y12, mediate ADP-driven platelet activation. The clinical effectiveness of P2Y12 blockade is well established. Recent preclinical data suggest that P2Y1
