871012-88-3

Usage

Molecular Structure

Consists of a pyridine ring with a phenyl group and an iodine atom attached to it.

Usage

Commonly used as a building block in organic synthesis and pharmaceutical research.

Potential

Acts as a key intermediate in the production of various drugs and biologically active molecules.

Application

Used as a reagent in the preparation of heterocyclic compounds and in the development of new materials.

Biological Activities

Investigated for its potential antitumor, anti-inflammatory, and antimicrobial properties, making it an important molecule in medicinal chemistry research.

Upstream product

• 18471-73-3 4-(pyridin-2-yl)aniline 
• 372-48-5 2-fluoropyridine 
• 624-38-4 para-diiodobenzene 
• 1186026-67-4 1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trimethylsilyl)benzene 
• 106-37-6 1.4-dibromobenzene 
• 170230-27-0 (4-(pyridin-2-yl)phenyl)boronic acid 
• 589-87-7 1,4-bromoiodobenzene 
• 5122-99-6 4-iodophenylboronic acid 
• 1338250-05-7 dimethyl 4-iodophenylboronate 
• 109-72-8 n-butyllithium 
• 13329-40-3 4-Iodoacetophenone 
• 109-76-2 Trimethylenediamine 

Downstream Products

• 871012-90-7 2-(4-trimethylsilylethynylphenyl)pyridine 
• 871012-92-9 2-(4-ethynylphenyl)pyridine 
• 1421006-78-1 (E)-2-(4-iodo-2-(2-methylstyryl)phenyl)pyridine 

Relevant academic research and scientific papers

Azimuthal Dipolar Rotor Arrays on Surfaces

A set of dipolar molecular rotor compounds was designed, synthesized and adsorbed as self-assembled 2D arrays on Ag(111) surfaces. The title molecules are constructed from three building blocks: (a) 4,8,12-trioxatriangulene (TOTA) platforms that are known to physisorb on metal surfaces such as Au(111) and Ag(111), (b) phenyl groups attached to the central carbon atom that function as pivot joints to reduce the barrier to rotation, (c) pyridine and pyridazine units as small dipolar units on top. Theoretical calculations and scanning tunneling microscopy (STM) investigations hint at the fact that the dipoles of neighboring rotors interact through space through pairs of energetically favorable head-to-tail arrangements.

A novel and robust heterogeneous Cu catalyst using modified lignosulfonate as support for the synthesis of nitrogen-containing heterocycles

A waste biomass, sodium lignosulfonate, was treated with sodium 2-formylbenzenesulfonate, and the phenylaldehyde condensation product was then used as a robust supporting material to immobilize a copper species. The so-obtained catalyst was characterized by many physicochemical methods including FTIR, EA, FSEM, FTEM, XPS, and TG. This catalyst exhibited excellent catalytic activity in the synthesis of nitrogen-containing heterocycles such as tricyclic indoles bearing 3,4-fused seven-membered rings, 2-arylpyridines, aminonaphthalenes and 3-phenylisoquinolines. In addition, this catalyst showed to be recyclable and could be reused several times without significant loss in activity during the course of the reaction process.

A Pyridine–Pyridine Cross-Coupling Reaction via Dearomatized Radical Intermediates

A pyridine–pyridine coupling reaction has been developed between pyridyl phosphonium salts and cyanopyridines using B2pin2 as an electron-transfer reagent. Complete regio- and cross-selectivity are observed when forming a range of valuable 2,4′-bipyridines. Phosphonium salts were found to be the only viable radical precursors in this process, and mechanistic studies indicate that the process does not proceed through a Minisci-type coupling involving a pyridyl radical. Instead, a radical–radical coupling process between a boryl phosphonium pyridyl radical and a boryl-stabilized cyanopyridine radical explains the C?C bond-forming step.

Mn-catalyzed aromatic C-H alkenylation with terminal alkynes

The first manganese-catalyzed aromatic C-H alkenylation with terminal alkynes is described. The procedure features an operationally simple catalyst system containing commercially available MnBr(CO)5 and dicyclohexylamine (Cy2NH). The reaction occurs readily in a highly chemo-, regio-, and stereoselective manner delivering anti-Markovnikov E-configured olefins in high yields. Experimental study and DFT calculations reveal that (1) the reaction is initiated by a C-H activation step via the cooperation of manganese and base; (2) manganacycle and alkynylmanganese species are the key reaction intermediates; and (3) the ligand-to-ligand H-transfer and alkynyl-assisted C-H activation are the key steps rendering the reaction catalytic in manganese.

Highly Branched Dendrimers

A dendrimer of formula (I): [DENDRON1]x-CORE-[B-[X]b]a (I) wherein: CORE is a metal ion or a group containing a metal ion, or is a non-polymeric organic group; B is a phenyl ring; a is an integer of from 1 to 8;

Investigating the effect of steric crowding in phosphorescent dendrimers

A simple convergent procedure has been developed for the formation of sterically encumbered phosphorescent dendrimers. The procedure is demonstrated with the preparation of a first-generation dendrimer composed of a fac-tris(2-phenylpyridyl)iridium(III) c