18471-73-3

Basic information

• Product Name: 4-(2-PYRIDYL)ANILINE
• Synonyms: 4-(2-PYRIDYL)ANILINE;2-(4-AMINOPHENYL)PYRIDINE;2-Pyridyl-3-aniline;4-(2-Pyridinyl)aniline;4-(pyridin-2-yl)aniline;4-Pyridin-2-yl-phenylaMine;4-(2-Pyridyl)
• CAS NO: 18471-73-3
• Molecular Formula: C₁₁H₁₀N₂
• Molecular Weight: 170.21
• Product Categories: pharmacetical
• Mol File: 18471-73-3.mol
• Article Data: 21

Chemical Properties

• Melting Point: 95 °C
• Boiling Point: 322.8 °C at 760 mmHg
• Flash Point: 175.1 °C
• Appearance: /
• Density: 1.133 g/cm³
• Vapor Pressure: 0.000272mmHg at 25°C
• Refractive Index: 1.625
• PKA: 5.72±0.25(Predicted)
• CAS DataBase Reference: 4-(2-PYRIDYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-PYRIDYL)ANILINE(18471-73-3)
• EPA Substance Registry System: 4-(2-PYRIDYL)ANILINE(18471-73-3)

Safety Data

• Hazardous Substances Data: 18471-73-3(Hazardous Substances Data)

Usage

Description

4-(2-Pyridyl)aniline, an aromatic amine compound with the chemical formula C11H10N2, is a pale yellow crystalline solid. It has a molecular weight of 170.21 g/mol and is commonly utilized in the production of dyes, pigments, and pharmaceuticals. Additionally, it serves as an intermediate in the synthesis of various organic compounds. However, due to its toxic nature, it poses potential health risks if ingested, inhaled, or absorbed through the skin, necessitating careful handling and usage in laboratory and industrial settings.

Uses

Used in Chemical Synthesis Industry:
4-(2-Pyridyl)aniline is used as an intermediate for the synthesis of various organic compounds, contributing to the development of new chemical entities and materials.
Used in Pharmaceutical Industry:
4-(2-Pyridyl)aniline is used as a building block in the production of pharmaceuticals, playing a crucial role in the creation of new drugs and medicinal compounds.
Used in Dye and Pigment Industry:
4-(2-Pyridyl)aniline is used as a key component in the formulation of dyes and pigments, providing coloration and stability to various products.

InChI:InChI=1/C11H10N2/c12-10-6-4-9(5-7-10)11-3-1-2-8-13-11/h1-8H,12H2

Upstream product

• 109-04-6 2-bromo-pyridine 
• 89415-43-0 (4-aminophenyl)boronic acid 
• 14805-00-6 5-nitro-2,2’-bipyridine 
• 57785-86-1 pyridin-2-yl tosylate 
• 109-09-1 2-chloropyridine 
• 24067-17-2 4-nitrophenylboronic acid 
• 540-37-4 p-aminoiodobenzene 
• 106-40-1 4-bromo-aniline 
• 214360-73-3 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline 
• 100-05-0 4-nitrobenzenediazonium chloride 
• 110-86-1 pyridine 
• 100-01-6 4-nitro-aniline 
• 1008-89-5 2-phenylpyridine 
• 882521-96-2 pyridine-2-boronic acid N-phenyldiethanolamine ester 

Downstream Products

• 1198837-72-7 N,N'-bis[4-(2-pyridyl)phenyl]acenaphthenequinonediimine 
• 98061-21-3 4-pyridin-2-yl-benzoic acid methyl ester 
• 4385-62-0 4-(pyridin-2-yl)benzoic acid 
• 95131-06-9 N-(4-butoxy-phenyl)-N'-(4-[2]pyridyl-phenyl)-thiourea 
• 95131-07-0 N-(4-sec-butoxy-phenyl)-N'-(4-[2]pyridyl-phenyl)-thiourea 
• 102079-46-9 N-(4-acetyl-phenyl)-N'-(4-[2]pyridyl-phenyl)-thiourea 
• 109939-93-7 N-(3-diethylamino-propyl)-N'-(4-[2]pyridyl-phenyl)-thiourea 
• 101424-27-5 N,N-bis-(2-hydroxy-ethyl)-N'-(4-[2]pyridyl-phenyl)-thiourea 
• 100714-55-4 N-(2-hydroxy-ethyl)-N'-(4-[2]pyridyl-phenyl)-thiourea 
• 99989-80-7 (4-[2]pyridyl-phenyl)-thiourea 

Relevant articles and documents

NOVEL HYDRAZONE DERIVATIVE WITH ARYL OR HETEROARYL GROUP SUBSTITUTED AT TERMINAL AMINE GROUP THEREOF AND USE THEREOF

The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.

Phenoxazine-based supramolecular tetrahedron as biomimetic lectin for glucosamine recognition

The design and synthesis of a phenoxazine-based metal-organic tetrahedron (Zn4L4) as biomimetic lectin for selectively recognition of glucosamine (GlcN) was reported. Different from the free phenoxazine-based ligand (L), Zn4L4 displayed the highest fluorescent intensity enhancement efficiency toward GlcN over other related natural mono- and disaccharides. Fluorescence titration demonstrated a 1:1 stoichiometric host-guest complex was formed with an association constant about 4.03 × 104 L/mol. 1H NMR spectroscopic studies confirmed this selectivity resulted from the multiple hydrogen bonding interactions formed between GlcN and Zn4L4. The present results suggested that rational arrangement of recognition sites in the confined space of metal-organic cage is crucial for the selectivity toward target guests.

Unified Protocol for Fe-Based Catalyzed Biaryl Cross-Couplings between Various Aryl Electrophiles and Aryl Grignard Reagents

The combination of commonly used FeCl3/SIPr with Ti(OEt)4/PhOM enabled a highly general iron-based catalyst system, which could efficiently catalyze the biaryl coupling reaction between various electrophiles (I, Br, Cl, OTs, OCONMe2, OSO2NMe2) and common or functionalized aryl Grignard reagents with high functional group tolerance. Selective couplings of aryl iodides and bromides over the corresponding oxygen-based electrophiles have been achieved, and thus a terphenyl acid intermediate for anidulafungin was conveniently synthesized via an orthogonal coupling strategy.