871332-81-9 Usage
Uses
Used in Pharmaceutical Industry:
3-Nitro-5-(pyrrolidin-1-ylcarbonyl)benzenboronic acid is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into complex molecular structures, contributing to the development of potential anti-cancer and anti-inflammatory drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Nitro-5-(pyrrolidin-1-ylcarbonyl)benzenboronic acid is utilized as a building block in the creation of new agrochemicals, potentially enhancing crop protection and yield through targeted pest and disease control.
Used in Organic Synthesis:
3-Nitro-5-(pyrrolidin-1-ylcarbonyl)benzenboronic acid serves as a reagent in organic synthesis, facilitating the formation of new compounds with specific properties, which can be applied across various chemical and material science applications.
Used in Medicinal Chemistry Research:
3-NITRO-5-(PYRROLIDIN-1-YLCARBONYL)BENZENEBORONIC ACID is employed in medicinal chemistry research as a structural component in the design and synthesis of novel drug candidates, leveraging its unique functional groups to explore new therapeutic avenues.
Check Digit Verification of cas no
The CAS Registry Mumber 871332-81-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,1,3,3 and 2 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 871332-81:
(8*8)+(7*7)+(6*1)+(5*3)+(4*3)+(3*2)+(2*8)+(1*1)=169
169 % 10 = 9
So 871332-81-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H13BN2O5/c15-11(13-3-1-2-4-13)8-5-9(12(16)17)7-10(6-8)14(18)19/h5-7,16-17H,1-4H2
871332-81-9Relevant academic research and scientific papers
A robust three-step telescoped synthesis of electron-deficient amide substituted arylboronic acids
Zhu, Jason,Razler, Thomas M.,Xu, Zhongmin,Conlon, David A.,Sortore, Eric W.,Fritz, Alan W.,Demerzhan, Roman,Sweeney, Jason T.
scheme or table, p. 438 - 442 (2012/02/03)
A robust three-step telescoped process for the preparation of electron-deficient amide-substituted arylboronic acids from readily available bromobenzoic acids has been developed. An EDC-HOBT-promoted amide formation of a bromobenzoic acid was followed by subjection of the product stream to a palladium-mediated cross-coupling with B2(pin)2. The resultant mixture of the arylboronate ester and arylboronic acid was directly treated with NaIO4, followed by a heptane-MeTHF crystallization, to cleanly afford the corresponding arylboronic acid in good yield. This general procedure was used to synthesize electron-deficient amide-substituted arylboronic acids with a diverse array of electron-withdrawing substituents.
