871339-60-5Relevant academic research and scientific papers
Synthesis and SAR of tolylamine 5-HT6 antagonists
Singer, Jamie M.,Wilson, Michael W.,Johnson, Paul D.,Graham, Shelley R.,Cooke, Leonard W.,Roof, Robin L.,Boxer, Peter A.,Gold, Lisa H.,Meltzer, Leonard T.,Janssen, Ann,Roush, Nicole,Campbell, Jeffrey E.,Su, Ti-Zhi,Hurst, Susan I.,Stoner, Chad L.,Schwarz, Jacob B.
scheme or table, p. 2409 - 2412 (2009/12/25)
The synthesis and SAR of tolylamines with 5-HT6 receptor antagonist activity is presented. The amine, core aromatic, peripheral aromatic, and ether linker moieties of HTS hit 1 were modulated and the effect on potency at 5-HT6 examin
KINASE MODULATORS AND METHODS OF USE
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Page/Page column 120, (2010/02/15)
The present invention relates to compounds of the Formula I and II wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.
