871571-00-5

Upstream product

• 108475-12-3 2,3-Dihydro-3-hydroxy-2-p-tolyl-1H-isoindol-1-one 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 62303-05-3 2-iodo-N-(p-tolyl)benzamide 
• 140-88-5 ethyl acrylate 
• 2142-03-2 2-p-tolylisoindoline-1,3-dione 
• 582-78-5 N-(4-methylphenyl)benzamide 
• 609-67-6 2-Iodobenzoyl chloride 
• 88-67-5 2-Iodobenzoic acid 

Downstream Products

• 132868-76-9 2,3-Dihydro-3-oxo-2-p-tolyl-1H-isoindole-1-acetyl Chloride 

Relevant academic research and scientific papers

Non-coordinating-Anion-Directed Reversal of Activation Site: Selective C?H Bond Activation of N-Aryl Rings

An Rh-catalyzed selective C?H bond activation of diaryl-substituted anilides is described. In an attempt to achieve C?H activation of C-aryl rings, we unexpectedly obtained an N-aryl ring product under non-coordinating anion conditions, whereas the C-aryl

Rh(III)-catalyzed tandem oxidative olefination-michael reactions between aryl carboxamides and alkenes

Rh(III)-catalyzed oxidative coupling reactions between benzamides or heteroaryl carboxamides and olefins have been developed. The vinylation product can further undergo a Michael reaction leading to γ-lactam in the case of electron-withdrawing olefins.

Palladium mediated synthesis of isoindolinones and isoquinolinones

The palladium-catalyzed reactions of 2-iodo-N-substituted benzamides 5-10 with acrylic esters 11-14 led to N-substituted-3-alkylisoindolinone esters 15-22 in good yields. The esters of isoindolinones 15-22 underwent hydrolysis reactions yielding the N-aryl-1,2,3,4-tetrahydro-1-oxoisoquinoline-3-carboxylic acid 26-31 in good yields.