871589-86-5Relevant articles and documents
Enantioselective, biocatalytic reduction of 3-substituted cyclopentenones: Application to the asymmetric synthesis of an hNK-1 receptor antagonist
Campos, Kevin R.,Klapars, Artis,Kohmura, Yoshinori,Pollard, David,Ishibashi, Hideaki,Kato, Shinji,Takezawa, Akihiro,Waldman, Jacob H.,Wallace, Debra J.,Chen, Cheng-Yi,Yasuda, Nobuyoshi
, p. 1004 - 1007 (2011/05/08)
A convergent and enantioselective route to the hNK-1 receptor antagonist (1) is described, which sets all six stereogenic centers with high diastereoselectivity and delivers 1 in only 11 steps and 23% overall yield. The process was enabled by the developm
PROCESS FOR MAKING LACTAM TACHYKININ RECEPTOR ANTAGONISTS
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Page/Page column 25; 34; 37; 54-55, (2008/06/13)
The present invention is directed to a process for preparing certain α,α disubstituted γ-lactam derivatives that are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The compounds are useful i
Lactam tachykinin receptor antagonists
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Page/Page column 22-23, (2010/02/15)
The present invention is directed to certain lactam compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations compri