871896-93-4Relevant academic research and scientific papers
Synthesis of Structurally Diverse Benzotriazoles via Rapid Diazotization and Intramolecular Cyclization of 1,2-Aryldiamines
Faggyas, Réka J.,Sloan, Nikki L.,Buijs, Ned,Sutherland, Andrew
, p. 5344 - 5353 (2019/05/21)
An operationally simple method has been developed for the preparation of N-unsubstituted benzotriazoles by diazotization and intramolecular cyclization of a wide range of 1,2-aryldiamines under mild conditions, using a polymer-supported nitrite reagent and p-tosic acid. The functional group tolerance of this approach was further demonstrated with effective activation and cyclization of N-alkyl, -aryl, and -acyl ortho-aminoanilines leading to the synthesis of N1-substituted benzotriazoles. The synthetic utility of this one-pot heterocyclization process was exemplified with the preparation of a number of biologically and medicinally important benzotriazole scaffolds, including an α-amino acid analogue.
Dihydrobenzo imidazolecarboxylic compd. and its use
-
, (2016/10/08)
PROBLEM TO BE SOLVED: To provide a benzimidazole compound for use as an antiplatelet agent or an antithrombotic agent, or for use in the treatment of cancer or cardiovascular and cerebrovascular diseases, and to provide a pharmaceutical composition con
Benzimidazole compounds and their use
-
, (2012/01/06)
Benzimidazole compounds of formula (I): wherein R1, R2, R3, R4, R5, X, Y, Z1, and Z2 are defined herein. Also disclosed is a pharmaceutical composition comprising the benzimidazo
BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS
-
Page/Page column 8, (2010/08/03)
Benzimidazole compounds of formula (I): wherein R1, R2, R3, R4, R5, X, Y, Z1, and Z2 are defined herein. Also disclosed is a method for treating cancer with benzimidazole compoun
