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benzoic acid (3aS,4R,6R,6aR)-6-(2,6-dichloro-purin-9-yl)-2,2-dimethyl-tetrahydro-thieno[3,4-d][1,3]dioxol-4-ylmethyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

596103-10-5

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596103-10-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 596103-10-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,9,6,1,0 and 3 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 596103-10:
(8*5)+(7*9)+(6*6)+(5*1)+(4*0)+(3*3)+(2*1)+(1*0)=155
155 % 10 = 5
So 596103-10-5 is a valid CAS Registry Number.

596103-10-5Relevant articles and documents

Structure-activity relationships of 2-chloro-N6-substituted-4′-thioadenosine-5′-N,N-dialkyluronamides as human A3 adenosine receptor antagonists

Jeong, Lak Shin,Lee, Hyuk Woo,Kim, Hea Ok,Tosh, Dilip K.,Pal, Shantanu,Choi, Won Jun,Gao, Zhan-Guo,Patel, Amit R.,Williams, Wanda,Jacobson, Kenneth A.,Kim, Hee-Doo

, p. 1612 - 1616 (2008/09/19)

On the basis of potent and selective A3 adenosine receptor (AR) antagonist, 2-chloro-N6-(3-iodobenzyl)-4′-thioadenosine-5′-N,N-dimethyluronamide, structure-activity relationships were studied for a series of 5′-N,N-dialkyluronamide d

Structure-activity relationships of 2-chloro-N6-substituted- 4′-thioadenosine-5′-uronamides as highly potent and selective agonists at the human A3 adenosine receptor

Jeong, Lak Shin,Lee, Hyuk Woo,Jacobson, Kenneth A.,Kim, Hea Ok,Shin, Dae Hong,Lee, Jeong A.,Gao, Zhan-Guo,Lu, Changrui,Duong, Heng T.,Gunaga, Prashantha,Lee, Sang Kook,Jin, Dong Zhe,Chun, Moon Woo,Moon, Hyung Ryong

, p. 273 - 281 (2007/10/03)

We have established structure-activity relationships of novel 4′-thionucleoside analogues as the A3 adenosine receptor (AR) agonists. Binding affinity, selectivity toward other AR subtypes, and efficacy in inhibition of adenylate cyclase were studied. Fro

Design, synthesis, and biological activity of N6-substituted-4′-thioadenosines at the human A3 adenosine receptor

Jeong, Lak Shin,Lee, Hyuk Woo,Kim, Hea Ok,Jung, Ji Young,Gao, Zhan-Guo,Duong, Heng T.,Rao, Srikar,Jacobson, Kenneth A.,Shin, Dae Hong,Lee, Jeong A,Gunaga, Prashantha,Lee, Sang Kook,Jin, Dong Zhe,Chun, Moon Woo,Moon, Hyung Ryong

, p. 4718 - 4730 (2007/10/03)

A large series of N6-substituted-4′-thioadenosines were synthesized starting from d-gulonic-γ-lactone, and structure-activity relationships were studied at the human A3 and other subtypes of adenosine receptors (ARs). 2-Chloro-substi

Purine nucleosides

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Page/Page column 6; 17; 27; Sheet 3 of 3, (2010/02/14)

Disclosed are purine nucleoside compounds that are selective to A3 adenosine receptors and are useful for the treatment of cancer and inflammatory diseases. The compounds are shown by the following general formula (I), including isomers thereof: wherein X is sulfur or oxygen; R1 is hydrogen, alkyl, benzyl, halobenzyl, or phenylalkyl; R2 is hydrogen, halogen, alkoxy, alkenyl, alkynyl, alkylthio, or thio; R3 and R3′ are hydrogen, hydroxyalkyl, alkoxycarbonyl, or alkylaminocabonyl, whereas R3 and R3′ do not have identical substituents simultaneously; and R4 is hydrogen or alkyl. Also disclosed are a pharmaceutical composition comprising a compound of formula (I), an isomer, or its pharmacologically acceptable salt as an active ingredient and a method for preventing or treating various diseases, state, or condition, including asthma, inflammation, cerebral ischemia, heart diseases, and cancer.

N6-substituted D-4′-thioadenosine-5′-methyluronamides: Potent and selective agonists at the human A3 adenosine receptor

Jeong, Lak Shin,Jin, Dong Zhe,Kim, Hea Ok,Shin, Dae Hong,Moon, Hyung Ryong,Gunaga, Prashantha,Chun, Moon Woo,Kim, Yong-Chul,Melman, Neli,Gao, Zhan-Guo,Jacobson, Kenneth A.

, p. 3775 - 3777 (2007/10/03)

4′-Thio analogues 3-5 of Cl-IB-MECA (2) (Ki = 1.0 ± 0.2 nM at the human A3 adenosine receptor) were synthesized from D-gulono-γ-lactone via 4-thioribosyl acetate 14 as the key intermediate. All synthesized 4′-thionucleosides exhibite

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