871926-92-0

Basic information

• Product Name: Spiro[3H-indole-3,3'-pyrrolidine]-1'-carboxylic acid, 1,2-dihydro-2-oxo-1-(phenylmethyl)-, phenylmethyl ester
• CAS NO: 871926-92-0
• Molecular Formula: C26H24N2O3
• Molecular Weight: 412.488
• Mol File: 871926-92-0.mol

Chemical Properties

• CAS DataBase Reference: Spiro[3H-indole-3,3'-pyrrolidine]-1'-carboxylic acid, 1,2-dihydro-2-oxo-1-(phenylmethyl)-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Spiro[3H-indole-3,3'-pyrrolidine]-1'-carboxylic acid, 1,2-dihydro-2-oxo-1-(phenylmethyl)-, phenylmethyl ester(871926-92-0)
• EPA Substance Registry System: Spiro[3H-indole-3,3'-pyrrolidine]-1'-carboxylic acid, 1,2-dihydro-2-oxo-1-(phenylmethyl)-, phenylmethyl ester(871926-92-0)

Safety Data

• Hazardous Substances Data: 871926-92-0(Hazardous Substances Data)

Upstream product

• 161609-91-2 benzyl 4-phenyl-3,6-dihydropyridine-1(2H)-carboxylate 
• 501-53-1 benzyl chloroformate 
• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 
• 31637-11-3 1-benzyloxycarbonyl-4-hydroxy-4-phenylpiperidine 
• 95798-23-5 1-(benzyloxycarbonyl)-4-hydroxypiperidine 
• 871927-01-4 3-benzyloxy-1-benzyloxycarbonyl-4-hydroxy-4-phenyl piperidine 
• 871926-95-3 1-((benzyloxy)carbonyl)-3-phenylpyrrolidine-3-carboxylic acid 
• 871926-94-2 3,4-dihydroxy-4-phenyl-piperidine-1-carboxylic acid benzyl ester 
• 871926-93-1 3-formyl-3-phenyl-pyrrolidine-1-carboxylic acid benzyl ester 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 1027057-30-2 3-benzylcarbamoyl-3-phenyl-pyrrolidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

Synthesis of (±)-coerulescine and a formal synthesis of (±)-horsfiline

A straightforward synthesis of (±)-coerulescine and (±)-horsfiline has been established from 3-formyl-3-phenylpyrrolidine employing 4-hydroxypiperidine as the starting material. There are two remarkable steps for the synthesis of (±)-coerulescine and (±)-horsfiline. One is the rapid access to produce 3-formyl-3-phenylpyrrolidine by Lewis acid-catalyzed rearrangement of 3,4-dihydroxy-4-phenylpiperidine. The other key step is an intramolecular electrophilic cyclization from 3-benzylcarbamoyl-3- phenylpyrrolidine to the 3,3-spirocyclic 2-oxindole ring skeleton.