871926-94-2

Upstream product

• 161609-91-2 benzyl 4-phenyl-3,6-dihydropyridine-1(2H)-carboxylate 
• 95798-23-5 1-(benzyloxycarbonyl)-4-hydroxypiperidine 
• 31637-11-3 1-benzyloxycarbonyl-4-hydroxy-4-phenylpiperidine 
• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 
• 501-53-1 benzyl chloroformate 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 733810-73-6 phenylmethyl 4-phenylhexahydropyridine-1-carboxylate 

Downstream Products

• 462647-76-3 (3-oxo-3-phenyl-propyl)-carbamic acid benzyl ester 
• 56296-78-7 Adofen 
• 886198-34-1 C₁₈H₁₇NO₄ 
• 871926-93-1 3-formyl-3-phenyl-pyrrolidine-1-carboxylic acid benzyl ester 
• 871926-92-0 1-benzyl-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-1'-carboxylic acid benzyl ester 
• 1027057-30-2 3-benzylcarbamoyl-3-phenyl-pyrrolidine-1-carboxylic acid benzyl ester 
• 871926-95-3 1-((benzyloxy)carbonyl)-3-phenylpyrrolidine-3-carboxylic acid 

Relevant academic research and scientific papers

CAN-mediated oxidative cleavage of 4-aryl-3,4-dihydroxypiperidines

A CAN-mediated oxidative cleavage of 4-aryl-3,4-dihydroxypiperidines 2Aa-Be to β-amino carbonyl compounds 3Aa-Be and 4Aa-Be in different ratios is described. This facile strategy was also used to synthesize racemic fluoxetine (5).

Synthesis of (±)-coerulescine and a formal synthesis of (±)-horsfiline

A straightforward synthesis of (±)-coerulescine and (±)-horsfiline has been established from 3-formyl-3-phenylpyrrolidine employing 4-hydroxypiperidine as the starting material. There are two remarkable steps for the synthesis of (±)-coerulescine and (±)-horsfiline. One is the rapid access to produce 3-formyl-3-phenylpyrrolidine by Lewis acid-catalyzed rearrangement of 3,4-dihydroxy-4-phenylpiperidine. The other key step is an intramolecular electrophilic cyclization from 3-benzylcarbamoyl-3- phenylpyrrolidine to the 3,3-spirocyclic 2-oxindole ring skeleton.