1027057-30-2

Upstream product

• 501-53-1 benzyl chloroformate 
• 161609-91-2 benzyl 4-phenyl-3,6-dihydropyridine-1(2H)-carboxylate 
• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 
• 31637-11-3 1-benzyloxycarbonyl-4-hydroxy-4-phenylpiperidine 
• 95798-23-5 1-(benzyloxycarbonyl)-4-hydroxypiperidine 
• 871927-01-4 3-benzyloxy-1-benzyloxycarbonyl-4-hydroxy-4-phenyl piperidine 
• 871926-94-2 3,4-dihydroxy-4-phenyl-piperidine-1-carboxylic acid benzyl ester 
• 871926-93-1 3-formyl-3-phenyl-pyrrolidine-1-carboxylic acid benzyl ester 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 871926-95-3 1-((benzyloxy)carbonyl)-3-phenylpyrrolidine-3-carboxylic acid 
• 100-46-9 benzylamine 

Downstream Products

• 871926-92-0 1-benzyl-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-1'-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis of (±)-coerulescine and a formal synthesis of (±)-horsfiline

A straightforward synthesis of (±)-coerulescine and (±)-horsfiline has been established from 3-formyl-3-phenylpyrrolidine employing 4-hydroxypiperidine as the starting material. There are two remarkable steps for the synthesis of (±)-coerulescine and (±)-horsfiline. One is the rapid access to produce 3-formyl-3-phenylpyrrolidine by Lewis acid-catalyzed rearrangement of 3,4-dihydroxy-4-phenylpiperidine. The other key step is an intramolecular electrophilic cyclization from 3-benzylcarbamoyl-3- phenylpyrrolidine to the 3,3-spirocyclic 2-oxindole ring skeleton.