871926-95-3

Upstream product

• 95798-23-5 1-(benzyloxycarbonyl)-4-hydroxypiperidine 
• 31637-11-3 1-benzyloxycarbonyl-4-hydroxy-4-phenylpiperidine 
• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 
• 52370-88-4 ethyl 3-phenylpyrrolidine-3-carboxylate 
• 22286-82-4 2-phenyl-acrylic acid ethyl ester 
• 161609-91-2 benzyl 4-phenyl-3,6-dihydropyridine-1(2H)-carboxylate 
• 501-53-1 benzyl chloroformate 
• 871927-01-4 3-benzyloxy-1-benzyloxycarbonyl-4-hydroxy-4-phenyl piperidine 
• 871926-94-2 3,4-dihydroxy-4-phenyl-piperidine-1-carboxylic acid benzyl ester 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 871926-93-1 3-formyl-3-phenyl-pyrrolidine-1-carboxylic acid benzyl ester 

Downstream Products

• 871926-92-0 1-benzyl-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-1'-carboxylic acid benzyl ester 
• 351360-83-3 tert-butyl (3-phenylpyrrolidin-3-yl)carbamate 
• 1027057-30-2 3-benzylcarbamoyl-3-phenyl-pyrrolidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

FACTOR IXA INHIBITORS

In its many embodiments, the present invention provides a novel class of benzamide compounds represented by Formula (I) or pharmaceutically acceptable salts or solvates thereof, or pharmaceutical compositions comprising one or more said compounds or pharmaceutically acceptable salts or solvates thereof, and methods for using said compounds or pharmaceutically acceptable salts or solvates thereof for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.

Synthesis of (±)-coerulescine and a formal synthesis of (±)-horsfiline

A straightforward synthesis of (±)-coerulescine and (±)-horsfiline has been established from 3-formyl-3-phenylpyrrolidine employing 4-hydroxypiperidine as the starting material. There are two remarkable steps for the synthesis of (±)-coerulescine and (±)-horsfiline. One is the rapid access to produce 3-formyl-3-phenylpyrrolidine by Lewis acid-catalyzed rearrangement of 3,4-dihydroxy-4-phenylpiperidine. The other key step is an intramolecular electrophilic cyclization from 3-benzylcarbamoyl-3- phenylpyrrolidine to the 3,3-spirocyclic 2-oxindole ring skeleton.