871933-36-7

Upstream product

• 939-80-0 4-chloro-3-nitrobenzonitrile 
• 96-99-1 4-chloro-3-nitrobenzoate 
• 16588-06-0 4-chloro-3-nitrobenzamide 

Downstream Products

• 871933-37-8 4-(4-bromophenyl)-2-(4-chloro-3-nitrophenyl)-thiazole 
• 871933-38-9 4-(4-bromophenyl)-2-(4-cyclohexylamino-3-nitrophenyl)-thiazole 
• 144060-69-5 ethyl 2-(4-chloro-3-nitrophenyl)-4-methylthiazole-5-carboxylate 
• 1361236-81-8 C₁₃H₁₁ClN₂O₄S 
• 1361236-80-7 C₁₂H₉ClN₂O₄S 
• 1361236-83-0 C₁₈H₁₃ClN₂O₄S 
• 1361236-82-9 C₁₃H₈ClF₃N₂O₄S 
• 1361237-16-2 C₁₂H₉ClN₂O₄S 
• 1361236-79-4 C₁₉H₁₆FN₃O₅S₂ 
• 1361236-78-3 C₂₀H₁₉N₃O₅S₂ 
• 1361236-77-2 C₁₈H₂₁N₃O₅S₂ 
• 1361236-75-0 C₂₁H₁₆F₃N₃O₅S₂ 
• 1361236-74-9 C₂₁H₁₆F₃N₃O₅S₂ 
• 1361236-73-8 C₂₀H₁₅F₄N₃O₅S₂ 

Relevant academic research and scientific papers

Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors

We previously identified a series of methylsulfonylnitrobenzoates (MSNBs) that block the interaction of the thyroid hormone receptor with its coactivators. MSNBs inhibit coactivator binding through irreversible modification of cysteine 298 of the thyroid hormone receptor (TR). Although MSNBs have better pharmacological features than our first generation inhibitors (β-aminoketones), they contain a potentially unstable ester linkage. Here we report the bioisosteric replacement of the ester linkage with a thiazole moiety, yielding sulfonylnitrophenylthiazoles (SNPTs). An array of SNPTs representing optimal side chains from the MSNB series was constructed using parallel chemistry and evaluated to test their antagonism of the TR-coactivator interaction. Selected active compounds were evaluated in secondary confirmatory assays including regulation of thyroid response element driven transcription in reporter constructs and native genes. In addition the selected SNPTs were shown to be selective for TR relative to other nuclear hormone receptors (NRs).

A mild and versatile synthesis of thioamides

Aliphatic and aromatic nitriles react with thioacetic acid in the presence of calcium hydride to give the corresponding thioamides in good to excellent yields. The examples studied include haloaryl nitriles in which the halogen is facile towards SNAr reactions under other conditions. Georg Thieme Verlag Stuttgart.

FUSED HETEROCYCLIC COMPOUND HAVING ANTI-HCV EFFECT

Disclosed is a compound represented by the formula (I) below, a pharmaceutically acceptable salt thereof, or a solvate of them. (I) (In the formula, A represents N or CH; Het represents any one of the following groups: (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k) wherein R0 and R respectively represent a hydrogen, an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted aryl or the like; R1 and R2 respectively represent a hydrogen, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl or the like; p is an integer of 0-3; and R3 represents an optionally substituted alkyl or the like.)