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16588-06-0

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16588-06-0 Usage

Description

4-CHLORO-3-NITROBENZAMIDE is a chemical compound characterized by the molecular formula C7H5ClN2O3. It features a benzene ring with a chlorine atom at the 4-position and a nitro group at the 3-position, which is connected to an amide group. 4-CHLORO-3-NITROBENZAMIDE is recognized for its high reactivity and is utilized in various applications due to its unique structural properties.

Uses

Used in Organic Synthesis:
4-CHLORO-3-NITROBENZAMIDE is used as a building block in organic synthesis for the creation of various pharmaceuticals and agrochemicals. Its unique structure allows it to be a versatile component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-CHLORO-3-NITROBENZAMIDE is employed as a reagent in chemical reactions. Its potential applications in this field are being explored due to its reactivity and the possibility of it serving as a precursor for the synthesis of new medicinal compounds.
Used in Chemical Reactions:
4-CHLORO-3-NITROBENZAMIDE is utilized as a reagent in chemical reactions, where its high reactivity is leveraged to facilitate specific transformations or to produce desired products in the synthesis process.
Used in the Production of Pharmaceuticals and Agrochemicals:
As a key component in the manufacturing process, 4-CHLORO-3-NITROBENZAMIDE is used in the production of various pharmaceuticals and agrochemicals, contributing to the development of new and effective products in these industries.

Check Digit Verification of cas no

The CAS Registry Mumber 16588-06-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,5,8 and 8 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 16588-06:
(7*1)+(6*6)+(5*5)+(4*8)+(3*8)+(2*0)+(1*6)=130
130 % 10 = 0
So 16588-06-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H5ClN2O3/c8-5-2-1-4(7(9)11)3-6(5)10(12)13/h1-3H,(H2,9,11)

16588-06-0 Well-known Company Product Price

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  • Alfa Aesar

  • (L14034)  4-Chloro-3-nitrobenzamide, 98%   

  • 16588-06-0

  • 1g

  • 414.0CNY

  • Detail
  • Alfa Aesar

  • (L14034)  4-Chloro-3-nitrobenzamide, 98%   

  • 16588-06-0

  • 5g

  • 1590.0CNY

  • Detail

16588-06-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Chloro-3-nitrobenzamide

1.2 Other means of identification

Product number -
Other names 4-CHLORO-3-NITROBENZAMIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16588-06-0 SDS

16588-06-0Relevant articles and documents

Design, Synthesis, and Biological Evaluation of Amidobenzimidazole Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists

Xi, Qiumu,Wang, Mingjin,Jia, Wenqiang,Yang, Mingjian,Hu, Jinping,Jin, Jing,Chen, Xiaoguang,Yin, Dali,Wang, Xiaojian

, p. 260 - 282 (2020)

Stimulator of interferon genes (STING) is an endoplasmic reticulum-localized adaptor protein (STING receptor) that has been shown to be activated by binding to natural cyclic dinucleotide (CDN) ligands and plays a vital role in innate immune sensing of exogenous or endogenous DNA, which then induces type I interferons and other cytokines. In this paper, we described a series of amidobenzimidazole STING agonists with high potency for the STING receptor and presented the relevant structure-activity relationships (SARs). The relative potencies of compounds 16g, 24b, and 24e were measured by a STING competition binding assay. A more thorough study of the effect on the STING signaling pathway demonstrated that three compounds, 16g, 24b, and 24e, significantly increased the protein levels and mRNA levels of IFN-β, CXCL10, and IL-6, and 24b as a representative compound effectively triggered the phosphorylation of STING, TBK1, and IRF3 in both human peripheral blood mononuclear cells (hPBMCs) and WT THP-1 cells. In addition, compound 24b demonstrated impressive antitumor efficacy in mice with established syngeneic colon tumors by intravenous administration. Furthermore, the pharmacokinetic profile of compound 24b was fully evaluated.

STING HETEROCYCLE AGONISTS AND USES THEREOF

-

Paragraph 00338, (2020/07/14)

The present invention provides compounds, compositions thereof, and methods of using the same for the modulation of STING, and the treatment of STING-mediated disorders.

Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors

Hwang, Jong Yeon,Attia, Ramy R.,Zhu, Fangyi,Yang, Lei,Lemoff, Andrew,Jeffries, Cynthia,Connelly, Michele C.,Guy, R. Kiplin

experimental part, p. 2301 - 2310 (2012/05/21)

We previously identified a series of methylsulfonylnitrobenzoates (MSNBs) that block the interaction of the thyroid hormone receptor with its coactivators. MSNBs inhibit coactivator binding through irreversible modification of cysteine 298 of the thyroid hormone receptor (TR). Although MSNBs have better pharmacological features than our first generation inhibitors (β-aminoketones), they contain a potentially unstable ester linkage. Here we report the bioisosteric replacement of the ester linkage with a thiazole moiety, yielding sulfonylnitrophenylthiazoles (SNPTs). An array of SNPTs representing optimal side chains from the MSNB series was constructed using parallel chemistry and evaluated to test their antagonism of the TR-coactivator interaction. Selected active compounds were evaluated in secondary confirmatory assays including regulation of thyroid response element driven transcription in reporter constructs and native genes. In addition the selected SNPTs were shown to be selective for TR relative to other nuclear hormone receptors (NRs).

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