872284-55-4

Upstream product

• 64-17-5 ethanol 
• 103085-19-4 (E)-4,4-dimethyl-3-phenyl-2-pentenoic acid 
• 2216-94-6 phenylpropynoic acid ethyl ester 
• 55164-19-7 ethyl-(Z)-3-chloro-3-phenyl-2-propenoate 
• 18819-66-4 (Z)-3-chloro-3-phenyl-2-propenoic acid 
• 938-16-9 2,2-dimethylpropiophenone 
• 3835-64-1 2,2-dimethyl-1-phenylpropan-1-ol 
• 92156-75-7 3-hydroxy-4,4-dimethyl-3-phenylpentanoic acid 
• 3282-30-2 pivaloyl chloride 
• 100-47-0 benzonitrile 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 

Downstream Products

• 384333-58-8 (Z)-4,4-dimethyl-3-phenylpent-2-en-1-ol 
• 23406-59-9 (R)-4,4-dimethyl-3-phenylpentanoic acid 
• 24425-68-1 (S)-4,4-dimethyl-3-phenylpentanoic acid 
• 137623-80-4 (3S)-4,4-dimethyl-3-phenylpentanal 
• 103085-19-4 (E)-4,4-dimethyl-3-phenyl-2-pentenoic acid 

Relevant academic research and scientific papers

Iridium-Catalyzed Asymmetric Isomerization of Primary Allylic Alcohols Using MaxPHOX Ligands: Experimental and Theoretical Study

The asymmetric isomerization of primary allylic alcohols to chiral aldehydes using iridium-catalysts bearing P,N-MaxPHOX ligands has been studied. These catalysts can be fine-tuned as they present three different stereogenic centers to modulate both the reactivity and enantioselectivity of a family of different substrates. The experimental part is supported by a DFT study of the reaction mechanism, which provides new insights into the key steps of this transformation.

Stereochemistry of the Reactions of CuI Catalyzed Grignard Reagents with Ethyl (E)- and (Z)-β-Chlorocinnamates

Ethyl (E)- and (Z)-3-chloro-3-phenyl-2-propenoate were prepared and separated.The (Z)-isomer gave β-alkylated ethyl cinnamates in good yield when reacted with alkyl Grignard reagents in the presence of 10percent CuI.The (Z)-isomer reacted with retention o

Stereochemistry of the Reaction of Diorganocuprate(I) Complexes Derived from Grignard Reagents with α,β-Acetylenic Esters

Diorganocuprate(I) complexes RCH3CuMgX, prepared from methylcopper and Grignard reagents (i-PrMgBr and t-BuMgCl) gave mainly cis-1,4-addition of the alkyl group originally present in the Grignard reagents and small amounts of cis- and trans-1,4-addition of the methyl group introduced by methylcopper, when they were allowed to react with ethyl propiolate and ethyl phenylpropiolate.The proportion of cis-1,4-addition products did not change when the reaction temperature was raised from -78 deg C to room temperature.The configurations of the main reaction products from the reaction with ethyl phenylpropiolate, ethyl (Z)-β-isopropylcinnamate and ethyl (Z)-β-t-butylcinnamate, were established by conversion of the corresponding acids to β-isopropylindenone and β-t-butylindenone.