3835-64-1

Basic information

• Product Name: 2,2-DIMETHYL-1-PHENYL-1-PROPANOL
• Synonyms: AURORA KA-6954;2,2-DIMETHYL-1-PHENYL-1-PROPANOL;Benzenemethanol, alpha-(1,1-dimethylethyl)-;α-(1,1-Dimethylethyl)benzenemethanol;α-tert-Butylbenzenemethanol;α-tert-Butylbenzyl alcohol;2,2-dimethyl-1-phenyl-propan-1-ol;2,2-dimethyl-1-phenylpropan-1-ol
• CAS NO: 3835-64-1
• Molecular Formula: C₁₁H₁₆O
• Molecular Weight: 164.24
• Product Categories: Alcohols;C9 to C30;Oxygen Compounds
• Mol File: 3835-64-1.mol
• Article Data: 269

Chemical Properties

• Melting Point: 43-45 °C(lit.)
• Boiling Point: 90 °C5 mm Hg(lit.)
• Flash Point: 206 °F
• Appearance: /
• Density: 0.9197 (rough estimate)
• Vapor Pressure: 0.0567mmHg at 25°C
• Refractive Index: 1.5179 (estimate)
• PKA: 14.43±0.20(Predicted)
• CAS DataBase Reference: 2,2-DIMETHYL-1-PHENYL-1-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIMETHYL-1-PHENYL-1-PROPANOL(3835-64-1)
• EPA Substance Registry System: 2,2-DIMETHYL-1-PHENYL-1-PROPANOL(3835-64-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 3835-64-1(Hazardous Substances Data)

Usage

Uses

2,2-Dimethyl-1-phenyl-1-propanol was used in the preparation of 2,2-dimethylpropiophenone.

General Description

Raney nickel and Raney cobalt catalyzed transfer hydrogenolysis of 2,2-dimethyl-1-phenyl-1-propanol has been reported. Kinetic resolution of 2,2-dimethyl-1-phenyl-1-propanol using a lead dioxide anode modified with poly-S-valine grafted on to a polypyrrole film has been reported. An efficient Cu(I)-catalyzed oxidation of 2,2-dimethyl-1-phenyl-1-propanol with di-tert-butyldiaziridinone as oxidant under mild conditions has been investigated.

InChI:InChI=1/C11H16O/c1-11(2,3)10(12)9-7-5-4-6-8-9/h4-8,10,12H,1-3H3

Upstream product

• 938-16-9 2,2-dimethylpropiophenone 
• 1068-56-0 isopropylmagnesium iodide 
• 920-39-8 isopropylmagnesium bromide 
• 677-22-5 tert-butylmagnesium chloride 
• 10557-57-0 propylmagnesium iodide 
• 100-52-7 benzaldehyde 
• 70712-85-5 1-phenyl-2,2-dimethyl-1-propyl bromide 
• 67242-59-5 N-methyl-N-(2-pyridyl)-formamide 
• 64-19-7 acetic acid 
• 611-70-1 phenyl isopropyl ketone 
• 106-46-7 para-dichlorobenzene 
• 630-19-3 pivalaldehyde 
• 108-90-7 chlorobenzene 
• 95-50-1 1,2-dichloro-benzene 

Downstream Products

• 70712-85-5 1-phenyl-2,2-dimethyl-1-propyl bromide 
• 938-16-9 2,2-dimethylpropiophenone 
• 23439-91-0 (1S)-2,2-dimethyl-1-phenyl-1-propanol 
• 1688-17-1 1-chloro-2,2-dimethyl-1-phenylpropane 
• 70712-76-4 2,2-Dimethyl-1-(4-neopentylphenyl)-1-phenylpropan 
• 17498-71-4 3-methyl-2-phenyl-1-butene 
• 769-57-3 α,β,β-trimethylstyrene 
• 53172-83-1 2-methyl-3-phenyl-1-butene 
• 3280-08-8 2-methyl-3-phenyl-butan-2-ol 
• 61986-33-2 2,2-dimethyl-1-(p-nitrophenyl)propan-1-ol 
• 61986-34-3 (R/S)-1-(2-nitrophenyl)-2,2-dimethyl-1-propanol 
• 15972-13-1 1-Cyclohexyl-2,2-dimethyl-1-propanol 
• 61501-04-0 2,2-dimethyl-1-phenyl-propylamine 
• 22876-56-8 1,2-dimethyl-1-phenyl-propylamine 

Relevant articles and documents

Developments in transfer hydrogenations of aromatic ketones catalyzed by boron compounds

Boron complexes BL1 and BL2 were prepared from O-donor ligands, 2,2′-(1E,1′E)-(ethane-1,2-diylbis(azan-1-yl-1-ylidene))bis(methane-1-yl-1-ylidene)diphenol (L1) and 2,2′-(propane-1,3-diylbis(azan-1-yl-1-ylidene))bis(methane-1-yl-1-ylidene)diphenol (L2). The complexes were fully characterized by 1H and 13C NMR, LC-MS/MS, TGA/DTA, UV-Vis, elemental analysis, SEM, and FTIR. The transfer hydrogenation of acetophenone derivatives was investigated by the boron complexes in the presence of isoPrOH, as the hydrogen source, under basic condition with NaOH. The results showed that the boron complexes were promising catalytic precursors for transfer hydrogenation of aromatic ketones in 0.1?M isoPrOH solution (up to 99%). Both steric and electronic factors of this class of molecules had a significant impact on the catalytic properties.

Enantioselective hydrogen transfer reactions from propan-2-ol to ketones catalyzed by pentacoordinate iridium(I) complexes with chiral Schiff bases

Some diastereoisomeric pentacoordinate complexes of the type *)I> (COD=cis,cis-1,5-cyclooctadiene; NNR*=2-pyridinal-1-phenylethylimine (PPEI) (I), 2-acetylpyridine-1-phenylethylimine (APPEI) (II)) have been synthesized.Th

Preparation of catechol boronate esters enabled by N → B dative bond as efficient, stable, and green catalysts for the transfer hydrogenation of various ketones

A series of new structurally related catechol boronate esters enabled by N → B dative bond of general composition (B1-B4) and (B1N-B4N) were designed and synthesized for the transfer hydrogenation of various ket

Reductive Arylation of Amides via a Nickel-Catalyzed Suzuki–Miyaura-Coupling and Transfer-Hydrogenation Cascade

We report a means to achieve the addition of two disparate nucleophiles to the amide carbonyl carbon in a single operational step. Our method takes advantage of non-precious-metal catalysis and allows for the facile conversion of amides to chiral alcohols via a one-pot Suzuki–Miyaura cross-coupling/transfer-hydrogenation process. This study is anticipated to promote the development of new transformations that allow for the conversion of carboxylic acid derivatives to functional groups bearing stereogenic centers via cascade processes.