3835-64-1

Usage

Uses

Used in Chemical Synthesis:
2,2-DIMETHYL-1-PHENYL-1-PROPANOL is used as a starting material for the preparation of various chemical compounds. Its unique structure allows for a range of reactions, making it a versatile component in the synthesis of different molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,2-DIMETHYL-1-PHENYL-1-PROPANOL is used as an intermediate in the synthesis of drugs. Its reactivity and compatibility with various catalysts make it a valuable asset in the development of new medications.
Used in Catalyst Research:
2,2-DIMETHYL-1-PHENYL-1-PROPANOL has been employed in the study of catalysts, such as Raney nickel and Raney cobalt, for transfer hydrogenolysis reactions. This research contributes to the understanding of catalyst behavior and the optimization of reaction conditions.
Used in Electrochemical Processes:
2,2-DIMETHYL-1-PHENYL-1-PROPANOL has also been used in the investigation of electrochemical processes, such as kinetic resolution using a lead dioxide anode modified with poly-S-valine grafted onto a polypyrrole film. This research helps in the development of more efficient and selective electrochemical methods.
Used in Oxidation Reactions:
2,2-DIMETHYL-1-PHENYL-1-PROPANOL has been studied in the context of efficient Cu(I)-catalyzed oxidation reactions with di-tert-butyldiaziridinone as an oxidant. This research contributes to the advancement of oxidation techniques under mild conditions, which is crucial for the synthesis of various organic compounds.

InChI:InChI=1/C11H16O/c1-11(2,3)10(12)9-7-5-4-6-8-9/h4-8,10,12H,1-3H3

Upstream product

• 938-16-9 2,2-dimethylpropiophenone 
• 1068-56-0 isopropylmagnesium iodide 
• 920-39-8 isopropylmagnesium bromide 
• 677-22-5 tert-butylmagnesium chloride 
• 10557-57-0 propylmagnesium iodide 
• 100-52-7 benzaldehyde 
• 2866-71-9 (1,1'-bicyclopentyl)-2-one 
• 83922-79-6 (1-diazo-2,2-dimethylpropyl)benzene 
• 507-20-0 tertiary butyl chloride 
• 67242-59-5 N-methyl-N-(2-pyridyl)-formamide 
• 64-19-7 acetic acid 
• 611-70-1 phenyl isopropyl ketone 
• 630-19-3 pivalaldehyde 
• 108-90-7 chlorobenzene 

Downstream Products

• 70712-85-5 1-phenyl-2,2-dimethyl-1-propyl bromide 
• 938-16-9 2,2-dimethylpropiophenone 
• 23439-91-0 (1S)-2,2-dimethyl-1-phenyl-1-propanol 
• 1688-17-1 1-chloro-2,2-dimethyl-1-phenylpropane 
• 54553-63-8 1-acetoxy-2,2-dimethylpropylbenzene 
• 23587-78-2 trimethyl-(2,2-dimethyl-1-phenylpropoxy)silane 
• 84713-92-8 2-Phenyl-butyric acid 2,2-dimethyl-1-phenyl-propyl ester 
• 128864-60-8 (R)-Fluoro-phenyl-acetic acid (R)-2,2-dimethyl-1-phenyl-propyl ester 
• 128864-60-8 (S)-Fluoro-phenyl-acetic acid (R)-2,2-dimethyl-1-phenyl-propyl ester 
• 105120-64-7 (1R,2S,4R,6S,7R)-4-((S)-2,2-Dimethyl-1-phenyl-propoxy)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]decane 
• 105094-70-0 <2S-(2α(S^*),3aα,4α,7α,7aα)>-7,8,8-Trimethyl-2-(2,2-dimethyl-1-phenylpropyloxy)-octahydro-4,7-methano-1-benzofuran 
• 77507-36-9 1-Phenyl-2,2-dimethylprop-1-yl α-<1-(9-anthryl)-2,2,2-trifluoroethoxy>acetate 
• 122505-28-6 1-(2,2-Dimethyl-1-phenyl-propoxy)-1,3-dihydro-benzo[c]thiophene 2,2-dioxide 
• 113775-62-5 <2R-(2α(S^*),3aα,4β,7β,7aα)>-2-(2,2-Dimethyl-1-phenylpropoxy)-octahydro-7,8,8-trimethyl-4,7-methanobenzofuran 

Relevant academic research and scientific papers

Developments in transfer hydrogenations of aromatic ketones catalyzed by boron compounds

Boron complexes BL1 and BL2 were prepared from O-donor ligands, 2,2′-(1E,1′E)-(ethane-1,2-diylbis(azan-1-yl-1-ylidene))bis(methane-1-yl-1-ylidene)diphenol (L1) and 2,2′-(propane-1,3-diylbis(azan-1-yl-1-ylidene))bis(methane-1-yl-1-ylidene)diphenol (L2). The complexes were fully characterized by 1H and 13C NMR, LC-MS/MS, TGA/DTA, UV-Vis, elemental analysis, SEM, and FTIR. The transfer hydrogenation of acetophenone derivatives was investigated by the boron complexes in the presence of isoPrOH, as the hydrogen source, under basic condition with NaOH. The results showed that the boron complexes were promising catalytic precursors for transfer hydrogenation of aromatic ketones in 0.1?M isoPrOH solution (up to 99%). Both steric and electronic factors of this class of molecules had a significant impact on the catalytic properties.

Ketone hydrogenation with iridium complexes with "non N-H" ligands: The key role of the strong base

Ferrocenyl phosphine thioether ligands (PS), not containing deprotonatable functions, efficiently support the iridium catalyzed ketone hydrogenation in combination with a strong base cocatalyst. Use of an internal base ([Ir(OMe)(COD)]2 in place

Enantioselective hydrogen transfer reactions from propan-2-ol to ketones catalyzed by pentacoordinate iridium(I) complexes with chiral Schiff bases

Some diastereoisomeric pentacoordinate complexes of the type *)I> (COD=cis,cis-1,5-cyclooctadiene; NNR*=2-pyridinal-1-phenylethylimine (PPEI) (I), 2-acetylpyridine-1-phenylethylimine (APPEI) (II)) have been synthesized.Th

Hydrogenation without a transition-metal catalyst: On the mechanism of the base-catalyzed hydrogenation of ketones

The hydrogenation of unsaturated organic substrates such as olefins and ketones is usually effected by homogeneous or heterogeneous transition-metal catalysts. On the other hand, a single case of a transition-metal-free and purely base-catalyzed hydrogena

Azetadiene iron carbonyl compounds and their preparation and application

The present invention discloses the structure of two novel azerodiene iron carbonyl compounds having a structure shown in formula (1): (R = adamantyl, 1-naphthyl), formula (1). The present invention discloses a method for preparing these two compounds: fi

Preparation of catechol boronate esters enabled by N → B dative bond as efficient, stable, and green catalysts for the transfer hydrogenation of various ketones

A series of new structurally related catechol boronate esters enabled by N → B dative bond of general composition (B1-B4) and (B1N-B4N) were designed and synthesized for the transfer hydrogenation of various ket

Manganese(I)-Catalyzed H-P Bond Activation via Metal-Ligand Cooperation

Here we report that chiral Mn(I) complexes are capable of H-P bond activation. This activation mode enables a general method for the hydrophosphination of internal and terminal α,β-unsaturated nitriles. Metal-ligand cooperation, a strategy previously not considered for catalytic H-P bond activation, is at the base of the mechanistic action of the Mn(I)-based catalyst. Our computational studies support a stepwise mechanism for the hydrophosphination and provide insight into the origin of the enantioselectivity.

PQXdpap: Helical Poly(quinoxaline-2,3-diyl)s Bearing 4-(Dipropylamino)pyridin-3-yl Pendants as Chirality-Switchable Nucleophilic Catalysts for the Kinetic Resolution of Secondary Alcohols

Helically chiral poly(quinoxaline-2,3-diyl)s bearing 4-(dipropylamino)pyridin-3-yl pendants at the 5-position of the quinoxaline ring (PQXdpap) exhibited high catalytic activities and moderate to high selectivities (up to s = 87) in the acylative kinetic resolution of secondary alcohols. The solvent-dependent helical chirality switching of PQXdpap between pure toluene and a 1:1 mixture of toluene and 1,1,2-trichloroethane enabled the preparation of either compound of a pair of enantiomerically pure alcohols (>99% ee) from a single catalyst.

PNO ligand containing planar chiral ferrocene and application thereof

The invention discloses a PNO ligand containing planar chiral ferrocene and application thereof. The PNO ligand containing planar chiral ferrocene is a planar chiral ferrocene-containing and phenol-containing PNO ligand as shown in a general formula (I) or (II) which is described in the specification, or a planar chiral ferrocene-containing and aryl-phosphoric-acid-containingPNO ligand containing as shown in a general formula (III) or (IV) which is described in the specification, or a planar chiral ferrocene-containing and carbon-chiral-phenol-containingPNO ligand as shown in a general formula (V) or (VI) which is described in the specification. The invention provides tridentate PNO ligands and processes for their complexation with transition metal salts or transition metal complexes; the introduction of salicylaldehyde and derivatives thereof, which are simple and easy to obtain, enables the ligands to have a bifunctionalization effect, and -OH in a formed catalyst has stronger acidity and is beneficial to combination with N/O in polar double bonds. Therefore, due to the bifunctionalization effect of the catalyst, the interaction between the catalyst and a substrate can be greatly improved, so a reaction can obtain higher catalytic activity and stereoselectivity.

PNO ligand containing planar chiral ferrocene and axial chiral diphenol and application thereof

The invention discloses a PNO ligand containing planar chiral ferrocene and axially chiral diphenol and application of the PNO ligand. The PNO ligand containing planar chiral ferrocene and axially chiral diphenol is shown in any one of general formulas (I)-(IV). Or a PNO ligand containing planar chiral ferrocene and axial chiral diphenol as shown in any one of general formulas (V)-(VIII); compared with a previously reported tridentate ligand, the PNO ligand containing the planar chiral ferrocene and the axial chiral diphenol not only has good stability and easiness in synthesis, but also has planar chirality and axial chirality and has a good chiral environment, so that not only is excellent selectivity to a substrate ensured, but also the catalytic activity of a catalyst and the application range of the substrate are further improved. The chiral raw materials used in the invention are commercial bulk products, and the ligand synthesis route is simpler, so that large-scale production can be well carried out, and the method has a huge commercial application prospect.