1005-91-0

Basic information

• Product Name: 2-(chloromethyl)-2-phenyloxirane
• Synonyms: 2-(Chloromethyl)-2-phenyloxirane; Oxirane, 2-(chloromethyl)-2-phenyl-
• CAS NO: 1005-91-0
• Molecular Formula: C₉H₉ClO
• Molecular Weight: 168.6202
• Mol File: 1005-91-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 256.4°C at 760 mmHg
• Flash Point: 73.5°C
• Density: 1.21g/cm³
• Vapor Pressure: 0.0248mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: 2-(chloromethyl)-2-phenyloxirane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(chloromethyl)-2-phenyloxirane(1005-91-0)
• EPA Substance Registry System: 2-(chloromethyl)-2-phenyloxirane(1005-91-0)

Safety Data

• Hazardous Substances Data: 1005-91-0(Hazardous Substances Data)

Usage

General Description

2-(chloromethyl)-2-phenyloxirane is a chemical compound that is also known as styrene oxide. It is an epoxide, meaning it contains a three-membered ring with one oxygen atom. 2-(chloromethyl)-2-phenyloxirane is commonly used in the production of various chemicals, including pharmaceuticals, resins, and polymers. It is also used as a stabilizer and as an intermediate in the synthesis of other organic compounds. Styrene oxide has been found to be carcinogenic in animal studies, and precautions should be taken to avoid exposure to this chemical. Additionally, it is important to handle and store 2-(chloromethyl)-2-phenyloxirane carefully in order to prevent any potential health hazards.

Upstream product

• 186581-53-3 diazomethane 
• 67-56-1 methanol 
• 60-29-7 diethyl ether 
• 532-27-4 1-chloroacetophenone 
• 563-79-1 2,3-Dimethyl-2-butene 
• 136749-73-0 3-(chloromethyl)-3-phenyl-1,2-dioxetane 
• 87234-28-4 1,3-dichloro-2-hydroxy-2-phenylpropane 
• 593-71-5 Chloroiodomethane 
• 98-88-4 benzoyl chloride 
• 591-51-5 phenyllithium 
• 591-50-4 iodobenzene 
• 108-86-1 bromobenzene 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 106418-53-5 sym-hydroxyphenyldibenzo-16-crown-5 
• 106418-47-7 sym-hydroxyphenyl-16-crown-5 
• 106418-51-3 sym-hydroxyphenyl-19-crown-6 
• 106418-55-7 sym-hydroxyphenyldibenzo-19-crown-6 
• 86488-90-6 1-phenyl-3-phenylthio-3-trimethylsilylcyclobutanol 
• 106418-52-4 sym-hydroxyphenyldibenzo-14-crown-4 
• 106418-43-3 sym-hydroxyphenyl-13-crown-4 
• 6006-81-1 3-hydroxy-2-phenylpropene 
• 112422-88-5 3-phenyl-3-hydroxyselenetane 
• 29526-96-3 1-phenylcyclopropan-1-ol 
• 191479-39-7 3-chloro-2-phenyl-1,2-propanediol 
• 856432-35-4 (1R*,5S*)-2-oxo-5-phenyl-3-oxa-bicyclo[3.1.0]hexane-1-carboxylic acid t-butyl ester 
• 876-43-7 1,3-difluoro-2-phenylpropan-2-ol 
• 1441287-78-0 1,3-difluoro-2-phenylpropan-2-yl N-phenylcarbamate 

Relevant articles and documents

Facile one-pot transformation of carboxylic acid chlorides into 2-substituted allyl alcohols

The reaction of carboxylic acid chlorides (1) with chloromethyl-lithium generated in situ (1:2 molar ratio) in the presence of lithium iodide leads, after hydrolysis, to the corresponding homologated 2-substituted allyl alcohols (2).

Asymmetric Desymmetrization via Metal-Free C?F Bond Activation: Synthesis of 3,5-Diaryl-5-fluoromethyloxazolidin-2-ones with Quaternary Carbon Centers

We disclose the first asymmetric activation of a non-activated aliphatic C?F bond in which a conceptually new desymmetrization of 1,3-difluorides by silicon-induced selective C?F bond scission is a key step. The combination of a cinchona alkaloid based ch

An improved method for the addition reactions of 1,3-dichloroacetone with combined organolithium-cerium trichloride reagents

Alkyl-, phenyl- and alkynyllithium reagents in combination with anhydrous cerium(III) chloride underwent addition reactions with 1,3-dichloroacetone in a very efficient manner. The addition products are versatile precursors for 2-substituted epichlorohydrins and glycidols. Fluconazole, a potent antifungal agent, was thus synthesized in 67% yield by addition of 1,3-dichloroacetone to 2,4-difluorophenyllithium in the presence of cerium(III) chloride, followed by substitution of the chlorine atoms with 1,2,4-triazole.