87271-55-4Relevant academic research and scientific papers
Efficient Biocatalytic Reductive Aminations by Extending the Imine Reductase Toolbox
Roiban, Gheorghe-Doru,Kern, Marcelo,Liu, Zhi,Hyslop, Julia,Tey, Pei Lyn,Levine, Matthew S.,Jordan, Lydia S.,Brown, Kristin K.,Hadi, Timin,Ihnken, Leigh Anne F.,Brown, Murray J. B.
, p. 4475 - 4479 (2017/12/07)
Chiral secondary and tertiary amines are ubiquitous in pharmaceutical, fine, and specialty chemicals, but their synthesis typically suffers from significant sustainability and selectivity challenges. Biocatalytic alternatives, such as enzyme-catalyzed reductive amination, offer several advantages over traditional chemistry, but industrial applicability has not yet been demonstrated. Herein, we report the use of cell lysates expressing imine reductases operating at 1:1 stoichiometry for a variety of amines and carbonyls. A collection of biocatalysts with diversity in coverage of small molecules and direct industrial applicability is presented.
A Pd-catalyzed cascade reaction of N-H insertion and oxidative dehydrogenative aromatization: A new entry to 2-amino-phenols
Ding, Dong,Lv, Xiaobing,Li, Jian,Qiu, Lin,Xu, Guangyang,Sun, Jiangtao
supporting information, p. 4084 - 4088 (2014/06/10)
A palladium-catalyzed cascade reaction of N-H insertion (NHI) and oxidative dehydrogenative aromatization (ODA) has been developed, which affords a straightforward and efficient way to access the carbazole precursors (2-arylamino-phenols) as well as to prepare 2-alkylamino-phenols from non-aromatic substrates. This journal is the Partner Organisations 2014.
Production of keto acids
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, (2008/06/13)
A method for the production of a keto acid having the general formula STR1 wherein R1 and R2 independently represent a straight or branched chain alkyl of 1-18 carbon atoms, a cycloalkyl of 4-8 carbon atoms or a phenyl, each of which may be substituted by at least one substituent selected from the group consisting of halogen atoms and alkyls having 1-4 carbon atoms, an aralkyl of 7-10 carbon atoms, alkoxyalkyl having 2-20 carbon atoms, tetrahydrofuryl alkyl, alkylcarboxy alkyl, alkylcarboxy benzyl, or R1 and R2 together with the adjacent nitrogen atom may form a heterocyclic ring, or one of R1 and R2 is hydrogen, but R1 and R2 may not simultaneously be methyl or ethyl or benzyl which comprises reacting a m-amino phenol having the general formula STR2 wherein R1 and R2 are the same as above, with phthalic anhydride, in an organic solvent in an amount of less than 0.5 parts by weight per part of m-amino phenol.
BORANE-TETRAHYDROFURAN AS A USEFUL REAGENT IN THE N-MONOALKYLATION OF AMINES AND AMINOALCOHOLS BY CARBONYL COMPOUNDS.
Morales, Hilda R.,Perez-Juarez, Martin,Cuellar, Laura,Mendoza, Lourdes,Fernandez, Hector,Contreras, Rosalinda
, p. 1213 - 1220 (2007/10/02)
A new procedure for the high-yield N-monoalkylation of primary aromatic and aliphatic amines is described.
