872726-32-4

Upstream product

• 135-02-4 ortho-anisaldehyde 
• 89245-23-8 methyl (4S)-4-(t-butyldimethylsilyloxy)-5-hydroxypentanoate 
• 82065-62-1 methyl (4S)-4-(t-butyldimethylsilyloxy)-5-oxopentanoate 
• 100-58-3 phenylmagnesium bromide 
• 196080-41-8 methyl (4S)-4,5-bis(t-butyldimethylsilyloxy)pentanoate 
• 405517-45-5 (-)-tert-butyl (R)-3-oxo-2-phenylpiperidine-1-carboxylate 
• 121440-87-7 (+)-(S,E)-N-benzyl-(1,3-diphenyl-2-propenyl)amine 
• 872726-29-9 But-3-enoic acid benzyl-((E)-(S)-1,3-diphenyl-allyl)-amide 
• 872726-30-2 (1R,2R,6S)-3-Benzyl-2-phenyl-7-oxa-3-aza-bicyclo[4.1.0]heptan-4-one 
• 872726-31-3 (2R,3S)-1-benzyl-2-phenylpiperidin-3-ol 
• 872726-28-8 (6S)-N-benzyl-6-phenyl-3,6-dihydropyridin-2-one 

Downstream Products

• 872726-33-5 CP 99994 dihydrochloride 
• 872726-33-5 CP 100263 dihydrochloride 

Relevant academic research and scientific papers

Diastereoconvergent synthesis of trans -5-hydroxy-6-substituted-2- piperidinones by addition-cyclization-deprotection process

A diastereoselective one-pot approach to access trans-5-hydroxy-6- substituted-2-piperidinones by an addition-cyclization-deprotection process has been developed, in which the stereogenic center at the C-6 position was solely controlled by α-OTBS group. The utility of this transformation is demonstrated by the asymmetric synthesis of the enantiomer of (-)-CP-99,994.

A concise and practical catalytic asymmetric synthesis of (-)-CP-99,994 and (-)-L-733,061

A concise and practical catalytic asymmetric synthesis of (-)-CP-99,994 and (-)-L-733,061 was achieved. Key features involve the Pd-catalyzed asymmetric allylic amination and the ring-closing metathesis as key steps.