87299-57-8

Basic information

• Product Name: 5-Sulfo-2-furancarboxylic acid
• Synonyms: 5-Sulfo-2-furancarboxylic acid;5-Sulfo-2-furoic acid;5-sulfofuran-2-carboxylic acid
• CAS NO: 87299-57-8
• Molecular Formula: C₅H₄O₆S
• Molecular Weight: 192.15
• Product Categories: Furans
• Mol File: 87299-57-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.786
• Refractive Index: 1.581
• PKA: -1.30±0.50(Predicted)
• CAS DataBase Reference: 5-Sulfo-2-furancarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Sulfo-2-furancarboxylic acid(87299-57-8)
• EPA Substance Registry System: 5-Sulfo-2-furancarboxylic acid(87299-57-8)

Safety Data

• Hazardous Substances Data: 87299-57-8(Hazardous Substances Data)

Usage

General Description

5-Sulfo-2-furancarboxylic acid, also known as SFCA, is a chemical compound with the molecular formula C6H4O7S. It is a furan derivative and contains a sulfo group and a carboxylic acid group. SFCA is commonly used as a precursor for the synthesis of various pharmaceutical compounds and also as a fundamental building block in the production of certain dyes. It is also utilized in the food industry as a flavoring agent and preservative. Due to its applications in pharmaceuticals, dyes, and food additives, SFCA is an important chemical compound with various industrial uses.

InChI:InChI=1/C5H4O6S/c6-5(7)3-1-2-4(11-3)12(8,9)10/h1-2H,(H,6,7)(H,8,9,10)

Upstream product

• 88-14-2 2-furanoic acid 
• 63-42-3 D-(+)-lactose 
• 526-99-8 meso-galactaric acid 
• 31795-44-5 5-formyl-2-furansulfonic acid sodium salt 

Downstream Products

• 645-12-5 5-nitro-2-furoic acid 
• 826-03-9 2,5-dinitrofuran 
• 110-15-6 succinic acid 
• 144-62-7 oxalic acid 
• 87299-80-7 5-Sulfofuran-2-carboxylic acid diamide 
• 69816-05-3 2-furancarboxylic acid 5-(chlorosulfonyl) methyl ester 
• 87299-63-6 methyl 5-sulfamoylfuran-2-carboxylate 
• 110-17-8 (2E)-but-2-enedioic acid 
• 88-14-2 2-furanoic acid 

Relevant articles and documents

Heterocyclic amides with anti-tuberculosis activity

Compounds having the general structure: wherein A is selected from the group consisting of oxygen, sulfur, and NR15, and R15 is selected from the group consisting of H, alkyl, aryl, substituted alkyl, and substituted aryl; B,D, and E are each independently selected from the group consisting of CH, nitrogen, sulfur and oxygen; R1 is selected from the group consisting of nitro, halo, alkyl ester, arylsulfanyl, arylsulfinyl, arylsulfonyl and sulfonic acid; t is an integer from 1 to 3; and X is a substituted amide, and methods of using the novel compounds for treating infections caused by microorganisms, including Mycobacterium tuberculosis.

Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents

In an effort to develop new and more potent therapies to treat tuberculosis, a library of compounds was screened for M. tuberculosis UDP-Gal mutase inhibition. Nitrofuranylamide 1 was identified as a hit in this screen, possessing good antituberculosis activity. This paper describes the synthesis and evaluation of an expanded set of nitrofuranylamides. We have discovered a number of nitrofuranylamides with submicromolar M. tuberculosis MIC values and acceptable therapeutic indexes. The MIC activity did not correlate with UDP-Gal mutase inhibition, suggesting an alternative primary cellular target was responsible for the antituberculosis activity. The compounds were only active against mycobacteria of the tuberculosis complex. On the basis of these results, four compounds were selected for in vivo testing in a mouse model of tuberculosis infection, and of these compounds one showed significant antituberculosis activity.