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Usage

Uses

Used in Pharmaceutical Synthesis:
3',4'-DIFLUORO[1,1'-BIPHENYL]-2-AMINE is used as a building block in the pharmaceutical industry for the synthesis of various drugs. Its unique structure allows for the creation of new compounds with specific therapeutic properties, contributing to the development of novel medications.
Used in Agrochemical Production:
In the agrochemical sector, 3',4'-DIFLUORO[1,1'-BIPHENYL]-2-AMINE serves as an intermediate in the synthesis of pesticides and other agrochemicals. Its incorporation can enhance the effectiveness of these products, leading to improved agricultural yields and pest control.
Used in Materials Science:
3',4'-DIFLUORO[1,1'-BIPHENYL]-2-AMINE is used as a component in the development of new materials with specific properties in materials science. Its fluorinated biphenyl core can influence the physical and chemical characteristics of the resulting materials, making them suitable for various applications.
Used in Medicinal Chemistry:
In medicinal chemistry, 3',4'-DIFLUORO[1,1'-BIPHENYL]-2-AMINE is utilized as an intermediate for the synthesis of complex organic compounds with potential medicinal applications. Its unique structure can be leveraged to design and develop new drugs with improved efficacy and selectivity.

Upstream product

• 577-19-5 2-nitrophenyl bromide 
• 1202674-73-4 3,4-difluoro-2'-nitrobiphenyl 
• 615-43-0 2-iodophenylamine 
• 168267-41-2 (3,4-difluorophenyl)boronic acid 
• 95-51-2 o-chloroaniline 
• 348-61-8 1-bromo-3,4-difluorobenzene 
• 884-29-7 N-benzylidene-2-chloroaniline 
• 552-16-9 ortho-nitrobenzoic acid 

Relevant academic research and scientific papers

Preparation method of fluorine-containing benzidine

The invention relates to the field of organic synthesis, in particular to a preparation method of fluorine-containing benzidine. The invention provides the preparation method of the fluorine-containing benzidine. The preparation method comprises the follo

Method for synthesizing 3,4-difluoro-2'-aminobiphenyl

The invention relates to a method for synthesizing 3,4-difluoro-2'-aminobiphenyl. The method comprises: carrying out a reaction on o-nitrobenzoic acid, an alkali and a solvent, removing the water, adding substituted halobenzene, a catalyst and a ligand, c

Synthesis of Fluorenes Starting from 2-Iodobiphenyls and CH2Br2 through Palladium-Catalyzed Dual C-C Bond Formation

A facile and efficient approach is developed for the synthesis of fluorene and its derivatives starting from 2-iodobiphenyls and CH2Br2. A range of fluorene derivatives can be synthesized under relatively mild conditions. The reaction proceeds via a tandem palladium-catalyzed dual C-C bond formation sequence through the key dibenzopalladacyclopentadiene intermediates, which are obtained from 2-iodobiphenyls through palladium-catalyzed C-H activation.

N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling

A series of N-sulfonyl-aminobiaryl derivatives have been examined as novel antitubulin agents. Compound 21 [N-(4′-cyano-3′-fluoro-biphenyl-2-yl)-4-methoxy-benzenesulfonamide] exhibits remarkable antiproliferative activity against four cancer cell lines (pancreatic AsPC-1, lung A549, liver Hep3B, and prostate PC-3) with a mean GI50 value of 57.5 nM. Additional assays reveal that 21 inhibits not only tubulin polymerization but also the phosphorylation of STAT3 inhibition with an IC50 value of 0.2 μM. Four additional compounds (8, 10, 19, and 35) are also able to inhibit this phosphorylation. This study describes novel N-sulfonyl-aminobiaryl (biaryl-benzenesulfonamides) as potent anticancer agents targeting both STAT3 and tubulin. (Chemical Equation Presented).