873209-08-6Relevant academic research and scientific papers
Adenine derived inhibitors of the molecular chaperone HSP90 - SAR explained through multiple X-ray structures
Dymock, Brian,Barril, Xavier,Beswick, Mandy,Collier, Adam,Davies, Nicholas,Drysdale, Martin,Fink, Alexandra,Fromont, Christophe,Hubbard, Roderick E.,Massey, Andrew,Surgenor, Allan,Wright, Lisa
, p. 325 - 328 (2007/10/03)
Multiple co-crystal structures of an adenine-based series of inhibitors bound to the molecular chaperone Hsp90 have been determined. These structures explain the observed SAR for previously described compounds and new compounds, which possess up to 8-fold
