87337-00-6Relevant academic research and scientific papers
Synthesis and tyrosinase inhibition activity of trans-stilbene derivatives
Ismail, Tabasum,Shafi, Syed,Srinivas, Jada,Sarkar, Dhiman,Qurishi, Yasrib,Khazir, Jabeena,Alam, Mohammad Sarwar,Kumar, Halmuthur Mahabalarao Sampath
, p. 97 - 102 (2016/01/25)
Synthesis of a focussed library of trans-stilbene compounds through Wittig and other base catalysed condensation reactions is presented. The synthesized stilbenes were screened for their inhibitory potential against murine tyrosinase activity to explore the structure activity relationship (SAR). Presence of electron withdrawing group (-CN) at the double bond and hydroxyl group or halogen atom especially at para-position on the aromatic rings was found to significantly elevate the inhibitory activity. Among all the compounds screened, compounds 2, 6, 8, 10, 11, 15 and 21 were found to exhibit appreciable inhibitory activity. Compound 21 ((E)-2,3-bis(4-Hydroxyphenyl)acryonitrile) was found to be the most active with an IC50 value of 5.06 μM which is less than half of the value 10.78 μM observed for resveratrol (common standard used in murine tyrosinase activity studies) under similar conditions. The results obtained from the present study reveal structural/functional group sensitivity for the tyrosinase inhibitory activity of stilbenoid moieties and are expected to be very helpful for the design and synthesis of novel, selective and effective tyrosinase inhibitors.
Synthesis and photochemical transformations of a few olefin-appended 11,12-dibenzoyldibenzobarrelenes
Jacob, Ambily Mary,George, Gisha,Jacob, Jomon P.,Mathew, Eason M.
, p. 199 - 202 (2015/06/02)
Several olefin-appended dibenzobarrelenes have been synthesised by Diels-Alder reaction between 9-alkenylanthracenes and dibenzoylacetylene under carefully controlled conditions and their photochemistry was examined. Olefin appendages acted as efficient quenchers of the triplet state of these barrelenes.
Synthesis and characterization of para-pyridine linked NHC palladium complexes and their studies for the Heck-Mizoroki coupling reaction
Liu, Ya-Ming,Lin, Yi-Chun,Chen, Wen-Ching,Cheng, Jen-Hao,Chen, Yi-Lin,Yap, Glenn P. A.,Sun, Shih-Sheng,Ong, Tiow-Gan
experimental part, p. 7382 - 7389 (2012/07/31)
This paper describes the synthesis of 1-(pyridine-4-ylmethyl) NHC and their Pd(ii) and Ag(i) complexes, which are fully characterized. Interestingly, we have also synthesized a Pd complex 3a-CO3 using a more direct treatment of K2CO3 with PdCl2. 3a-CO 3 represents the first reported solid structure of a Pd η2-carbonato complex stabilized by an NHC framework. 3a-CO 3 can be easily converted to a PdCl2 derivative by treating it with chloroform. We have found these palladium complexes mediate the Heck-Mizoroki coupling with a low catalyst loading. Furthermore, we also expand such catalytic manifold toward constructing fused polyaromatic substrates, a highly useful class of compounds in optoelectronic chemistry.
Highly chemo- and stereoselective palladium-catalyzed transfer semihydrogenation of internal alkynes affording cis -alkenes
Li, Jie,Hua, Ruimao,Liu, Tao
supporting information; experimental part, p. 2966 - 2970 (2010/06/19)
DMF (N,N-dimethylformamide)/KOH was found to be an efficient hydrogen source in the Pd(OAc)2-catalyzed transfer semihydrogenation of various functionalized internal alkynes to afford cis-alkenes in good to high yields with excellent chemo- and stereoselectivity. This catalytic process was also applied to the synthesis of analogues of combretastatin A-4.
On the Relationship between Molecular Geometry and Excited-State Properties of 9-Anthrylalkenes
Becker, Hans-Dieter,Andersson, Kjell
, p. 4542 - 4549 (2007/10/02)
The excited-state properties of a series of 1-substituted and 1,1-disubstituted 2-(9-anthryl)alkenes have been investigated in terms of their fluorescence spectra and photochemical isomerizations.Large Stokes shifts of up to 10000 cm-1 between absorption and emission maxima are attributed to geometrical differences between the ground state and the emitting excited state.The : ratio of the photostationary state was found to depend markedly on the nature of the 1-substituent.Photochemical isomerization of 1,3- and 1,5-bis(9-anthryl)-substituted trans olefins results in the formation of intramolecular or cycloaddition products.The cycloaddition reactions of carbonyl-substituted anthracenes are suggested to involve the triplet excited state.
PHASE TRANSFER CATALYSED POLYMER-SUPPORTED WITTIG REACTIONS
Clarke, Stephen D.,Harrison, Charles R.,Hodge, Philip
, p. 1375 - 1378 (2007/10/02)
Arylsubstituted olefins can be prepared in high yield using phase transfer catalysed polymer-supported Wittig reactions.
