873695-05-7

Basic information

• Product Name: tert-butyl (4-bromobut-3-yn-1-yl)(tosyl)carbamate
• Synonyms: tert-butyl (4-bromobut-3-yn-1-yl)(tosyl)carbamate
• CAS NO: 873695-05-7
• Molecular Weight: 402.309
• Mol File: 873695-05-7.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl (4-bromobut-3-yn-1-yl)(tosyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (4-bromobut-3-yn-1-yl)(tosyl)carbamate(873695-05-7)
• EPA Substance Registry System: tert-butyl (4-bromobut-3-yn-1-yl)(tosyl)carbamate(873695-05-7)

Safety Data

• Hazardous Substances Data: 873695-05-7(Hazardous Substances Data)

Upstream product

• 338463-00-6 N-(tert-butoxycarbonyl)-N-but-3-ynyl-4-methylbenzenesulfonamide 
• 18303-04-3 N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide 

Downstream Products

• 1607830-06-7 N-(3-bromobut-3-en-1-yl)-4-methyl-N-(4-(4-methyl-N-(oct-1-yn-1-yl)phenylsulfonamido)but-1-yn-1-yl)benzenesulfonamide 
• 1043906-47-3 C₂₀H₂₃NO₅S 
• 873694-88-3 N-(4-bromobut-3-ynyl)-N-hexa-2,4-dienyl-4-methylbenzenesulfonamide 
• 873695-06-8 N-(4-bromobut-3-yn-1-yl)-4-methylbenzenesulfonamide 

Relevant articles and documents

Palladium-catalyzed cyclization of bromoenynamides to tricyclic azacycles: Synthesis of trikentrin-like frameworks

Palladium-catalyzed cascade cyclization of bromoenynamides equipped with an additional alkyne or ynamide substituent affords azatricyclic products. Using 5- to 7-membered ring tethers, this chemistry offers a regiospecific route to highly-functionalized azacycles. Elaboration to the trikentrin B skeleton is achieved from the arylsilane cyclization products. the Partner Organisations 2014.

Efficient synthesis of monosubstituted 3-alkynylfurans via Suzuki coupling

A convenient synthesis of monosubstituted 3-alkynyl-furans by Suzuki coupling reaction of 3-furanylboronic acid with substituted acetylene bromides is described. The internal alkyne products were attainable in 50-89% yields from substrates free of relatively acidic protons. Our protocol is expected to find applications in the synthesis of structurally related natural products.

Rhodium-catalyzed intramolecular [4 + 2] cycloadditions of alkynyl halides

(Chemical Equation Presented) Cationic rhodium(I)-catalyzed intramolecular [4 + 2] cycloadditions of diene-tethered alkynyl halides were found to occur in good yields (70-87%). The halide moiety is compatible with the cycloaddition reactions, and no oxidative insertion to the alkynyl halide was observed. The halogen-containing cycloadducts could be transformed into a variety of products that are difficult or impossible to obtain via direct cycloaddition.