87378-72-1

Upstream product

• 96791-19-4 trans-4-phenyl-3-benzamido-3-carbomethoxy-Δ¹-pyrazoline 
• 13257-30-2 (E)-N-benzoyldidehydrophenylalanine methyl ester 
• 15732-43-1 (E)-2-phenyl-4-benzylidene-5(4H)-oxazolone 
• 87378-79-8 methyl (Z)-1-<1-(N-imidazolyl)benzylideneamino>-2-phenylcyclopropanecarboxylate 
• 186581-53-3 diazomethane 
• 4607-84-5 (Z)-1-benzamido-2-phenylcyclopropanecarboxylic acid 
• 17606-70-1 (4Z)-4-benzylidene-2-phenyl-1,3-oxazol-5(4H)-one 
• 86557-47-3 (Z)-4-benzylidene-2-benzylthio-5(4H)-thiazolone 
• 3200-80-4 (Z)-1-amino-2-phenylcyclopropanecarboxylic acid 
• 63140-84-1 (Z)-5-benzylthio-1-phenyl-7-oxo-6-thia-4-azaspiro<2.4>hept-4-ene 
• 67-56-1 methanol 
• 4525-04-6 (Z)-1,5-diphenyl-6-oxa-4-azaspiro<2.4>hept-4-en-7-one 

Downstream Products

• 110769-86-3 (Z)-2,3-methanophenylalanine methyl ester 
• 110769-84-1 methyl (1R,2R)-1-amino-2-phenylcyclopropanecarboxylate 
• 4525-04-6 (Z)-(1,5-diphenyl)-7-oxo-6-oxa-4-azaspiro<2.4>hept-4-ene 
• 3200-80-4 (Z)-1-amino-2-phenylcyclopropanecarboxylic acid 
• 87378-80-1 (Z)-1,5-diphenyl-6-oxa-4-azaspiro<2.4>hept-4-ene 
• 87378-79-8 methyl (Z)-1-<1-(N-imidazolyl)benzylideneamino>-2-phenylcyclopropanecarboxylate 
• 3200-81-5 (1RS,2RS)-1-amino-2-phenyl-1-cyclopropanecarboxylic acid hydrochloride 
• 4607-84-5 (Z)-1-benzamido-2-phenylcyclopropanecarboxylic acid 
• 3790-22-5 3-amino-5-phenyl-dihydro-furan-2-one; hydrochloride 
• 3200-81-5 (E)-1-amino-2-phenylcyclopropanecarboxylic acid hydrochloride 
• 4607-84-5 (E)-1-benzamido-2-phenylcyclopropanecarboxylic acid 

Relevant academic research and scientific papers

Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C

A series of dipeptide nitriles with a thienyl alanine in P2 were identified as potent and selective cathepsin C inhibitors. Incorporation of a substituted cyclopropyl moiety in P1 effectively protects these derivatives against hydrolase activity in whole blood.

NEW EFFICIENT SYNTHESIS OF METHYL TRANS-2-ARYL (OR HETARYL)-1-BENZAMIDOCYCLOPROPANCARBOXYLATES.

Methyl trans-2-aryl (or hetaryl)-1-benzamidocyclopropancarboxylates can be easily obtained by thermal decomposition of trans-4-aryl(or hetaryl)-3-benzamido-3-carbomethoxy-Δ1-pyrazolines synthesized by 1,3-dipolar cycloaddition of diazomethane w

ON THE SYNTHESIS OF METHYL (Z/E)-2-ACETAMIDO(OR BENZAMIDO)-3-ARYL 2-BUTENOATES

The methyl Z-2-acetamido(or benzamido)-3-aryl-2-butenoates (Z-9a-e, Z-10a-e) were obtained by two alternative procedures: stereospecific opening of Z-2-methyl(or phenyl)-4-(α-arylethylidene)-5(4H)-oxazolones (Z-7a-e, Z-8a-e) and stereospecific homologatio

Action of Diazomethane on Methyl (Z(or E))-2-(Acylamino)cinnamates. A New Route to Methyl (Z)-2-(Acylamino)-3-methylcinnamates

Diazomethane reacts with methyl (Z(or E))-2-acetamido(or benzamido)cinnamates (1,2) to afford regio- and stereospecifically (Z(or E))-4-phenyl-3-acetamido(or benzamido)-3-carbomethoxy-Δ1-pyrazolines (3,4). 3Z and 4Z undergo pyrolysis to afford

Reaction of 4-Methylene-5(4H)-oxazolones With Diazomethane

The reaction of diazomethane with some (E) and (Z)-2-substituted-4-methylene-5(4)-oxazolones (1a-c) under two different conditions, has been studied. (E) and (Z)-1,2-disubstituted-7-oxo-6-oxa-4-azaspiro-hept-4-enes (3a-c, 4a-c) were mainly obtained, together with multiple addition compounds.The reaction showed to be stereoselective only when the substituents were aromatic.Acid hydrolysis of compounds 3a and 4a produced a mixture of (E) and (Z)-3,5-disubstituted-tetrahydrofuran-2-ones (8a, 9a).Smooth methanolysis of the ring led to (E) and (Z)-1-benzamido-cyclopropanecarboxylic esters (10a-c, 11a-c), which, on acid hydrolysis, gave (E) and (Z)-1-amino-2-phenylcyclopropanecarboxylic acids 12a and 13a.The pmr spectra have been analyzed by an iterative computer method, and the computed best values obtained have been used to deduce the stereochemistry of the spiroderivatives.