873924-07-3

Basic information

• Product Name: 3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 9-oxo-, 1,1-diMethylethyl ester
• Synonyms: 3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 9-oxo-, 1,1-diMethylethyl ester;tert-butyl 9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylate;tert-Butyl 9-oxo-3-azaspiro[5.5]undeca-7-ene-3-carboxylate;EOS-60496
• CAS NO: 873924-07-3
• Molecular Formula: C15H23NO3
• Molecular Weight: 265.34802
• Mol File: 873924-07-3.mol
• Article Data: 21

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 9-oxo-, 1,1-diMethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 9-oxo-, 1,1-diMethylethyl ester(873924-07-3)
• EPA Substance Registry System: 3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 9-oxo-, 1,1-diMethylethyl ester(873924-07-3)

Safety Data

• Hazardous Substances Data: 873924-07-3(Hazardous Substances Data)

Usage

General Description

3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 9-oxo-, 1,1-diMethylethyl ester is a chemical compound that belongs to the class of spiro compounds. It is a derivative of 3-azaspiro[5.5]undecane, an organic compound containing a spiro core that is commonly found in drugs and biologically active molecules. The 1,1-diMethylethyl ester functional group indicates that it contains two isopropyl groups attached to the ester group. 3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 9-oxo-, 1,1-diMethylethyl ester may have potential applications in the pharmaceutical industry, as well as in organic synthesis and chemical research. Its unique structure and properties make it an interesting target for further study and exploration.

Upstream product

• 6457-49-4 4-piperidinemethanol 
• 124443-68-1 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate 
• 2971-79-1 isonipecotic acid methyl ester 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 78-94-4 methyl vinyl ketone 
• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 

Downstream Products

• 873924-08-4 9-oxo-3-azaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester 
• 1225437-12-6 9-(3,3-Difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane 
• 1225437-01-3 tert-Butyl 9-(azetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane-3-carboxylate 
• 1225437-11-5 tert-Butyl 9-(3,3-difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane-3-carboxylate 
• 1225437-13-7 tert-Butyl 9-(3-fluorophenyl)-9-(pyrrolidin-1-yl)-3-azaspiro[5.5]undecane-3-carboxylate 
• 1225436-55-4 1-(9-(azetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecan-3-yl)-2-(((S)-1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone 
• 1225436-57-6 1-[3-(3-fluorophenyl)-3-pyrrolidin-1-yl-9-azaspiro[5.5]undecan-9-yl]-2-[1-[[3-(trifluoromethyl)phenyl]sulfonyl]-piperidin-2-yl]-ethanone 
• 1225436-56-5 1-(9-(3,3-difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecan-3-yl)-2-(((S)-1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone 
• 1184103-24-9 tert-butyl 3'-(3-methoxyphenyl)-2'-pyridin-4-yl-8',9'-dihydro-1H,6'H-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazoline]-1-carboxylate 
• 1184103-26-1 tert-butyl 3'-(3-methoxyphenyl)-2'-pyridin-4-yl-5',6'-dihydro-8'H-spiro[piperidine-4,7'-pyrazolo[5,1-b]quinazoline]-1-carboxylate 
• 1184103-29-4 3'-(3-methoxyphenyl)-2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazoline] 
• 1184103-34-1 3-(2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazolin]-3'-yl)phenol 
• 1272758-41-4 9-amino-3-azaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester 

Relevant articles and documents

COMBINATIONS OF DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS AND ACETYL-COA CARBOXYLASE INHIBITOR

Described herein are pharmaceutical compositions comprising 2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(3S,5S)-5-fluoropiperidin-3-yl]pyrimidine-5-carboxamide, or pharmaceutically acceptable salt thereof, for treatment of liver disease and diseases related thereto. Also described are compositions comprising 2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(3S,5S)-5-fluoropiperidin-3-yl]pyrimidine-5-5 carboxamide, or pharmaceutically acceptable salt thereof and 4-(4-(1-Isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoic acid, or pharmaceutically acceptable salt thereof, for treatment of liver disease and diseases related thereto.

Combinations For Treatment Of NASH/NAFLD And Related Diseases

The combination of (S)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-N-(tetrahydrofuran-3-yl)pyrimidine-5-carboxamide or pharmaceutically acceptable salt thereof, and 4-(4-(1-Isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4′-piperidine]-1′-carbonyl)-6-methoxypyridin-2-yl)benzoic acid or pharmaceutically acceptable salt thereof, for treatment of diseases, including non-alcoholic steatohepatitis (NASH), in mammals are described herein.

CRYSTALLINE 2-AMINO-2-(HYDROXYMETHYL)PROPANE-1,3-DIOL SALT OF 4-(4-(1-ISOPROPYL-7-OXO-1,4,6,7-TETRAHYDROSPIRO[INDAZOLE-5,4'-PIPERIDINE]-1'-CARBONYL)-6-METHOXYPYRIDIN-2-YL)BENZOIC ACID

The invention provides the tris salt of 4-(4-(1-isopropyl-7-oxo-1,4,6,7- tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoic acid as a crystalline anhydrous or tri-hydrate; as well as polymorphs, pharmaceutical compositions, dosage forms, and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase (ACC) enzyme(s) in an animal.