874113-02-7Relevant academic research and scientific papers
Tandem benzophenone amino pyridines, potent and selective inhibitors of human leukotriene C4 synthase
Kleinschmidt, Thea K.,Haraldsson, Martin,Basavarajappa, Devaraj,Lundeberg, Erik,Thulasingam, Madhuranayaki,Ekoff, Maria,Fauland, Alexander,Lehmann, Christoph,Kahnt, Astrid S.,Lindbom, Lennart,Haeggstr?m, Jesper Z.
, p. 108 - 116 (2015/09/28)
Cysteinyl leukotrienes (cys-LTs) are lipid mediators of inflammation. The enzyme catalyzing synthesis of cys-LTs, leukotriene C4 synthase (LTC4S), is considered an important drug target. Here we report the synthesis and characterization of thre
POTASSIUM CHANNEL MODULATORS
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Page/Page column 45, (2011/06/19)
Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein ring Z1, R1, p, R3, and R4 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.
BENZOXAZOCINES AND THEIR USE AS MONOAMINE-REUPTAKE INHIBITORS
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Page 36 - 37, (2010/02/07)
Compounds of the general formula (1), wherein one of W, X, Y and Z is N or CR4 and the others are each CH; and R4 is a specified substituent. These compounds inhibit monoamine reuptake, and are useful in the treatment of pain, emesis depression, post traumatic stress disorders, attention deficit disorders, obsessive compulsive disorders, pre-menstrual syndrome, substance abuse and sexual dysfunction.
