87428-99-7

Usage

Uses

An impurity of the antidiarrheal Racecadotril (R070600).

Upstream product

• 5669-19-2 2-Benzyl-2-propenoic acid 
• 1738-68-7 Gly-OBz 
• 607-81-8 diethyl 2-benzylmalonate 
• 100-51-6 benzyl alcohol 
• 1738-76-7 glycine benzyl ester p-toluenesulfonic acid salt 
• 88320-94-9 2-benzylpropenoyl chloride 
• 2462-31-9 benzyl 2-aminoacetate hydrochloride 
• 616-75-1 2-benzylmalonic acid 

Downstream Products

• 81110-73-8 racecadotril 

Relevant academic research and scientific papers

Method for synthesizing racecadotril

The invention provides a method for synthesizing racecadotril. The method comprises the following steps: I, enabling a compound (II) to react with an acylation reagent so as to obtain a compound (III); II, enabling he compound (III) to react with benzyl g

A PROCESS FOR THE PREPARATION OF N-[2-[(ACETYLTHIO) METHYL]-1-OXO-3-PHENYLPROPYL] GLYCINE PHENYL METHYL ESTER AND INTERMEDIATES THEREOF

The present invention relates to a process for the preparation of N-[2-[(acetylthio) methyl]-1-oxo-3-phenylpropyl] glycine phenyl methyl ester and intermediates thereof. More particularly the present invention relates to a process for the preparation of intermediate compound 2-(benzyl acrylolyl amino) acetic acid benzyl ester.

Structural studies of racecadotril and its process impurities by NMR and mass spectroscopy

Three unknown impurities in racecadotril bulk drug at levels below 0.5% were detected by simple reverse phase isocratic high performance liquid chromatography (HPLC). Structures for these impurities were proposed by molecular ion information and their fragmentation pattern obtained by LC-MS and these impurities were confirmed by NMR spectroscopy. The impurities I, II and III were characterized as benzyl 2-methyl carboximido acetate, benzyl 2-phenyl ethyl carboximido acetate, and benzyl 2-(1-benzyl vinyl carboximido) acetate. These structures were further confirmed by co-injecting of synthetic standards of impurities with racecadotril. The mechanism of the formation of these process related impurities is discussed.

Amino acid derivative

Derivatives having the general formula: STR1 in which the various radicals A,B,X,R1, R2, R3 and n have indicated definitions. These compounds have in particular enkephalinase-inhibiting, antalgic, antidepressive, antidiarrhea and hypotensive activities.