874487-04-4Relevant academic research and scientific papers
Radical N-heterocyclic carbene catalysis for β-ketocarbonyl synthesis
Ishii, Takuya,Nagao, Kazunori,Ohmiya, Hirohisa
, (2021/06/07)
N-Heterocyclic carbene-catalyzed radical cross-coupling between aldehydes and α-bromoesters or α-bromoamides is described. β-Ketocarbonyl compounds having a quaternary carbon center at the α-position can be synthesized under mild reaction conditions. Both aromatic and aliphatic aldehydes are suitable acyl donors by employing proper NHC catalyst precursors.
