87475-56-7

Basic information

• Product Name: 2-(2-chlorophenylsulfonyl)acetonitrile
• Synonyms: 2-(2-chlorophenylsulfonyl)acetonitrile
• CAS NO: 87475-56-7
• Molecular Formula: C₈H₆ClNO₂S
• Molecular Weight: 215.65674
• Mol File: 87475-56-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-chlorophenylsulfonyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-chlorophenylsulfonyl)acetonitrile(87475-56-7)
• EPA Substance Registry System: 2-(2-chlorophenylsulfonyl)acetonitrile(87475-56-7)

Safety Data

• Hazardous Substances Data: 87475-56-7(Hazardous Substances Data)

Upstream product

• 107-14-2 chloroacetonitrile 
• 2905-23-9 2-chlorophenylsulfonyl chloride 
• 1624363-23-0 3-azido-2-methylbut-3-en-2-ol 
• 1956-97-4 2-chlorobenzenediazonium tetrafluoroborate 
• 615-41-8 2-iodochlorobenzene 
• 18527-20-3 2-[(2-chlorophenyl)sulfanyl]acetonitrile 
• 6320-03-2 2-chlorothiphenol 

Downstream Products

• 1416903-54-2 C₁₃H₇ClN₄O₃S₂ 
• 1416903-25-7 C₁₇H₁₄ClN₅O₃S₂ 
• 1416903-62-2 C₁₃H₆Cl₂N₄O₂S₂ 
• 95066-72-1 2-(2-chloro-benzenesulfonyl)-3,3-bis-methylsulfanyl-acrylonitrile 
• 95066-73-2 3,3-Bis-benzylsulfanyl-2-(2-chloro-benzenesulfonyl)-acrylonitrile 
• 87475-58-9 3-Benzylsulfanyl-1,1-dioxo-1H-1λ⁶-benzo[1,4]dithiine-2-carbonitrile 
• 95083-54-8 2-(2-Chloro-benzenesulfonyl)-3,3-bis-ethylsulfanyl-acrylonitrile 

Relevant articles and documents

A Concise Route to 2-Sulfonylacetonitriles from Sodium Metabisulfite

A three-component reaction of aryldiazonium tetrafluoroborates, sodium metabisulfite, and 3-azido-2-methylbut-3-en-2-ol under mild conditions is described. By using abundant and cheap sodium metabisulfite as the sulfur dioxide surrogate, this protocol features good functional group compatibility, affording 2-arylsulfonylacetonitriles in moderate to good yields. The reaction proceeds smoothly at room temperature without the need of any catalysts or additives. Moreover, the synthetic utility of this method is demonstrated by the transformation of 2-arylsulfonylacetonitrile into 2-arylsulfonyl acetamide and 2-arylsulfonylethylamine. (Figure presented.).

3-SUBSTITUTED 2-AMINO-INDOLE DERIVATIVES

The present invention provides compounds of formula (I) (Formula (I)) and pharmaceutically acceptable salts thereof, wherein Q, X% X4,X5 X6, X7,R1, R2, R3 and R8 are as defined in the specification, processes for the preparation of such compounds, pharmaceutical compositions containing them and the use of such compounds in therapy.

Use of (Z)-β-(2-fluorobenzenesulfonyl)vinylamines as novel synthons in the synthesis of 1,4-benzothiazine derivatives

A novel synthetic route for arylated 1,4-benzothiazine derivatives has been developed. This method utilizes a key intramolecular nucleophilic aromatic substitution step of the corresponding (Z) - (2-fluorobenzenesulfonyl)vinylamine intermediate to construct the benzothiazine ring. A wide range of aryl and heteroaryl substituent groups can be installed from commercial boronic acids. Both mono- and diarylated products have been synthesized in good yields and with good functional group tolerance. Georg Thieme Verlag Stuttgart · New York.