875155-18-3Relevant articles and documents
6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists
Orain, David,Ofner, Silvio,Koller, Manuel,Carcache, David A.,Froestl, Wolfgang,Allgeier, Hans,Rasetti, Vittorio,Nozulak, Joachim,Mattes, Henri,Soldermann, Nicolas,Floersheim, Philipp,Desrayaud, Sandrine,Kallen, Joerg,Lingenhoehl, Kurt,Urwyler, Stephan
, p. 996 - 999 (2012/03/26)
A new set of quinazolinedione sulfonamide derivatives as competitive AMPA receptor antagonist with improved properties compared to 1 is disclosed. By modulating physico-chemical properties, compound 29 was identified with a low ED50 of 5.5 mg/kg in an animal model of anticonvulsant activity after oral dosage.