288615-45-2

Upstream product

• 25449-96-1 3-amino-4-methylbenzotrifluoride 
• 288615-43-0 N-(2-methyl-5-trifluoromethyl-phenyl)-acetamide 
• 288615-44-1 2-Methyl-4-nitro-5-trifluoromethylacetanilide 
• 875155-19-4 2-amino-5-nitro-4-trifluoromethyl-benzoic acid methyl ester 
• 875155-18-3 2-acetylamino-5-nitro-4-trifluoromethyl-benzoic acid 

Downstream Products

• 875155-59-2 N-(2-amino-5-nitro-4-trifluoromethyl-benzoyl)-methanesulfonhydrazide 
• 875155-19-4 2-amino-5-nitro-4-trifluoromethyl-benzoic acid methyl ester 
• 875155-23-0 2-acetylamino-5-[1,2,4]triazol-4-yl-4-trifluoromethyl-benzoic acid methyl ester 
• 875155-27-4 2-isocyanato-5-nitro-4-trifluoromethyl-benzoic acid methyl ester 
• 875155-24-1 2-amino-5-[1,2,4]triazol-4-yl-4-trifluoromethyl-benzoic acid methyl ester 
• 875155-22-9 2-acetylamino-5-[1,2,4]triazol-4-yl-4-trifluoromethyl-benzoic acid 
• 875155-21-8 2-acetylamino-5-amino-4-trifluoromethyl-benzoic acid methyl ester 
• 875155-20-7 2-acetylamino-5-nitro-4-trifluoromethyl-benzoic acid methyl ester 

Relevant academic research and scientific papers

6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists

A new set of quinazolinedione sulfonamide derivatives as competitive AMPA receptor antagonist with improved properties compared to 1 is disclosed. By modulating physico-chemical properties, compound 29 was identified with a low ED50 of 5.5 mg/kg in an animal model of anticonvulsant activity after oral dosage.

QUINAZOLINE DERIVATIVES

The present invention relates to 1H-Quinazoline-2,4-dione derivatives of formula (I) wherein the substituents are defined as in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them.

6-substituted heteroquinolinecarboxylic acid derivatives and addition salts thereof and processes for the preparation of both

The invention provides compounds with antagonism against excitatory amino acid receptors, in particular, AMPA receptor having 6-substituted heteroquinolinecarboxylic acid derivatives and addition salts thereof as effective ingredients, and processes for the preparation of both. These compounds relate to 6-substituted heteroquinolinecarboxylic acid derivatives represented by a general formula (1) (wherein A denotes a single bond or methylene (CH2), Y denotes a nitrogen atom or ═CH—, V denotes a single bond or methylene (CH2), T denotes a hydroxyl group, amino group, lower alkoxycarbonyl group, carboxyl group, aldehyde group or the like, R denotes a nitro group, trifluoromethyl group or halogen atom, and R1denotes a hydroxyl group or lower alkoxy group), and addition salts thereof.