875288-47-4

Basic information

• Product Name: (3S,4S)-4-methyl-4-phenyl-3-tris(trimethylsilyl)siloxybutanal
• Synonyms: (3S,4S)-4-methyl-4-phenyl-3-tris(trimethylsilyl)siloxybutanal
• CAS NO: 875288-47-4
• Molecular Weight: 424.878
• Mol File: 875288-47-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3S,4S)-4-methyl-4-phenyl-3-tris(trimethylsilyl)siloxybutanal(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,4S)-4-methyl-4-phenyl-3-tris(trimethylsilyl)siloxybutanal(875288-47-4)
• EPA Substance Registry System: (3S,4S)-4-methyl-4-phenyl-3-tris(trimethylsilyl)siloxybutanal(875288-47-4)

Safety Data

• Hazardous Substances Data: 875288-47-4(Hazardous Substances Data)

Upstream product

• 1873-77-4 tris-(trimethylsilyl)silane 
• 37778-99-7 (S)-2-phenyl-1-propanol 
• 861445-91-2 tris(trimethylsilyl)-vinyloxy-silane 
• 93-53-8 (S)-2-phenyl-propionaldehyde 

Downstream Products

• 934297-80-0 C₂₃H₄₄O₂Si₄ 

Relevant articles and documents

"Super silyl" group for diastereoselective sequential reactions: Access to complex chiral architecture in one pot

We have shown that the tris(trimethylsilyl)silyl (TTMSS) silyl enol ether of acetaldehyde undergoes aldehyde cross-aldol reactions with high selectivity and the extremely low catalyst loading (0.05 mol % of HNTf2) allows for one-pot sequential reactions where acidic or basic nucleophiles can be subsequently added. Various ketone-derived silyl enol ethers, Grignard reagents, and dienes succeeded, generating relatively complex molecular architectures in a single step. This represents the first case where, in a single pot, highly acidic conditions followed by very basic conditions were tolerated to give products with high diastereoselectivities and good yields. Copyright