875573-32-3Relevant academic research and scientific papers
Design, synthesis, and biological activity of novel factor Xa inhibitors: Improving metabolic stability by S1 and S4 ligand modification
Komoriya, Satoshi,Kobayashi, Shozo,Osanai, Ken,Yoshino, Toshiharu,Nagata, Tsutomu,Haginoya, Noriyasu,Nakamoto, Yumi,Mochizuki, Akiyoshi,Nagahara, Takayasu,Suzuki, Makoto,Shimada, Takashi,Watanabe, Kengo,Isobe, Yumiko,Furugoori, Taketoshi
, p. 1309 - 1330 (2007/10/03)
Serine protease factor xa (fXa) inhibitor 1 showed good ex vivo anti-fXa activity upon oral administration in rats. However, it has been revealed that 1 had low metabolic stability against human liver microsomes. To improve the metabolic stability, we att
