87562-51-4

Basic information

• Product Name: 2,2-dimethyl-5-phenylpentanenitrile
• Synonyms: 2,2-dimethyl-5-phenylpentanenitrile
• CAS NO: 87562-51-4
• Molecular Weight: 187.285
• Mol File: 87562-51-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2,2-dimethyl-5-phenylpentanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dimethyl-5-phenylpentanenitrile(87562-51-4)
• EPA Substance Registry System: 2,2-dimethyl-5-phenylpentanenitrile(87562-51-4)

Safety Data

• Hazardous Substances Data: 87562-51-4(Hazardous Substances Data)

Upstream product

• 78-82-0 Isobutyronitrile 
• 637-59-2 1-Bromo-3-phenylpropane 
• 181717-14-6 3-(2-iodophenyl)propyl methanesulfonate 
• 181717-12-4 2-(o-iodophenyl)ethyl methanesulfonate 
• 495414-08-9 5-(2-iodophenyl)-2,2-dimethylpentanenitrile 
• 115860-48-5 1-iodo-3-(2-iodophenyl)propane 
• 96606-95-0 3-(2-iodophenyl)propanoic acid 
• 18698-96-9 o-iodophenylacetic acid 
• 26059-41-6 3-(2-iodophenyl)-1-propanol 
• 128823-38-1 3-(2-iodophenyl)propanenitrile 
• 26059-40-5 2-(2-iodophenyl)ethan-1-ol 

Downstream Products

• 1379004-80-4 2,2-dimethyl-5-phenylpentanal 
• 1206670-48-5 2-benzyl-4,4-dimethyl-1-(4-methylbenzenesulfonyl)pyrrolidine 

Relevant articles and documents

Controlled Reduction of Nitriles by Sodium Hydride and Zinc Chloride

A new protocol for the controlled reduction of nitriles to aldehydes was developed using a combination of sodium hydride and zinc chloride. The iminyl zinc intermediates derived from aromatic nitriles could be further functionalized with allylmetal nucleophiles to afford homoallylamines. As the method allows the reduction of various aliphatic and aromatic nitriles with a concise procedure under milder reaction conditions and exhibits wide functional group compatibility, it is well suited for use in various opportunities in chemical synthesis.

An Iodine-Catalyzed Hofmann-L?ffler Reaction

Iodine reagents have been identified as economically and ecologically benign alternatives to transition metals, although their application as molecular catalysts in challenging C-H oxidation reactions has remained elusive. An attractive iodine oxidation catalysis is now shown to promote the convenient conversion of carbon-hydrogen bonds into carbon-nitrogen bonds with unprecedented complete selectivity. The reaction proceeds by two interlocked catalytic cycles comprising a radical chain reaction, which is initiated by visible light as energy source. This unorthodox synthetic strategy for the direct oxidative amination of alkyl groups has no biosynthetic precedence and provides an efficient and straightforward access to a general class of saturated nitrogenated heterocycles.

Quaternary ammonium antiarrhythmic drugs

Quaternary ammonium salts of certain phenylbutylamines are useful antiarrhythmic drugs. A method for treating arrhythmia and prolonging the action potential of cardiac tissue is provided. Pharmaceutical formulations containing such quaternary ammonium salts are disclosed.