128823-38-1Relevant articles and documents
The use of cobalt-mediated cycloisomerisation of ynedinitriles in the synthesis of pyridazinohelicenes
Chercheja, Serghei,Klivar, Jiri,Jancarik, Andrej,Rybacek, Jiri,Salzl, Simon,Tarabek, Jan,Pospisil, Lubomir,Vacek Chocholousova, Jana,Vacek, Jaroslav,Pohl, Radek,Cisarova, Ivana,Stary, Ivo,Stara, Irena G.
supporting information, p. 8477 - 8482 (2014/07/08)
A cobalt-mediated [2+2+2] cycloisomerisation of ynedinitriles to helical pyridazines in good to high yields was developed. The construction of the pyridazine nucleus from one alkyne and two nitrile units is proposed to follow either a conventional organometallic mechanism or to be triggered by a single-electron transfer from a CoII species. Various [5]-, [6]- and [7]helicene pyridazines were prepared.
Indium(III)-catalyzed one-pot synthesis of alkyl cyanides from carboxylic Acids
Moriya, Toshimitsu,Shoji, Kohei,Yoneda, Shinichiro,Ikeda, Reiko,Konakahara, Takeo,Sakai, Norio
, p. 3233 - 3238 (2013/12/04)
The one-pot preparation of alkyl cyanides from carboxylic acids via alkyl iodides or alkyl bromides, which were in situ generated either by indium(III)-catalyzed reductive iodination or bromination of carboxylic acids, is described. Georg Thieme Verlag Stuttgart New York.
Carbopalladation of nitriles: Synthesis of benzocyclic ketones and cyclopentenones via Pd-catalyzed cyclization of ω-(2-iodoaryl)alkanenitriles and related compounds
Pletnev, Alexandre A.,Larock, Richard C.
, p. 9428 - 9438 (2007/10/03)
An efficient procedure for the synthesis of 2,2-disubstituted benzocyclic ketones by intramolecular carbopalladation of nitriles has been developed. The cyclization of substituted 3-(2-iodoaryl)-propanenitriles affords indanones in high yields. The reaction is compatible with a wide variety of functional groups. This methodology has been extended to the synthesis of tetralones and cyclopentenones.
Application of the palladium-catalyzed borylation/Suzuki coupling (BSC) reaction to the synthesis of biologically active biaryl lactams
Baudoin, Olivier,Cesario, Michele,Guenard, Daniel,Gueritte, Francoise
, p. 1199 - 1207 (2007/10/03)
The palladium-catalyzed, two-step, one-pot borylation/Suzuki coupling (BSC) reaction was developed to synthesize sterically hindered 2,2′-disubstituted biphenyl and phenyl-indole compounds in a short, simple, and efficient manner from two easily accessible aryl halides. High yields can be obtained by choosing properly both components according to their rough electronic properties. The illustration of the utility of this method was provided by the solution and solid-phase synthesis of seven- or eight-membered biphenyl lactams 5a-e, as well as paullone 3a. These compounds exhibit moderate albeit significant cytotoxicities and may serve as structural models for future medicinal chemistry developments.
Synthesis of medium-ring nitrogen heterocycles via palladium-catalyzed heteroannulation of 1, 2-dienes
Larock, Richard C.,Tu, Chi,Pace, Paola
, p. 6859 - 6866 (2007/10/03)
Seven-, eight-, and nine-membered-ring nitrogen heterocycles are readily prepared by the palladiumcatalyzed heteroannulation of a variety of 1, 2-dienes by a range of tosylamide- and amine-containing aryl and vinylic halides. The ease of ring formation is
