875929-65-0

Upstream product

• 702-69-2 7-methyl-1,4-dioxa-spiro[4.5]decan-8-one 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 805229-68-9 7-hydroxymethyl-7-methyl-1,4-dioxaspiro[4.5]decan-8-one 

Downstream Products

• 875929-73-0 [8-allyloxycarbonyloxy-9-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-1,4-dioxa-spiro[4.5]dec-7-en-7-yl]-acetic acid ethyl ester 
• 875929-66-1 9-allyl-7-(tert-butyl-diphenyl-silanyloxymethyl)-7-methyl-1,4-dioxa-spiro[4.5]decan-8-one 
• 875929-74-1 [9-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-8-oxo-1,4-dioxa-spiro[4.5]dec-7-yl]-acetic acid ethyl ester 

Relevant academic research and scientific papers

Total synthesis of (±)-jiadifenin and studies directed to understanding its SAR: Probing mechanistic and stereochemical issues in palladium-mediated allylation of enolate-like structures

The total synthesis of jiadifenin has been accomplished. The synthesis allows us to build an SAR profile which suggests that the jiadifenin skeleton may be less desirable from the standpoint of nominating a potential drug than that of its prerearrangement