876288-78-7

Upstream product

• 475641-59-9 (Z)-(2R,4aR,6S,7R,11aS)-7-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononene 
• 100-39-0 benzyl bromide 
• 876288-76-5 (1R,3S,4R,6Z,9S,11S)-4-benzyloxy-3-benzyloxymethyl-11-phenyl-2,10,12-trioxabicyclo[7.4.0]tridecan-6-ene 
• 876288-75-4 (1R,3S,4R,6Z,9S,11S)-3-hydroxymethyl-11-phenyl-2,10,12-trioxabicyclo[7.4.0]tridecan-6-en-4-ol 
• 876288-77-6 (2R,3S,5Z,8R,9S)-8-benzyloxy-9-benzyloxymethyl-2-hydroxymethyl-2,3,4,7,8,9-hexahydrooxonin-3-ol 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 876288-79-8 2,2-Dimethyl-propionic acid (Z)-(2R,3S,8R,9S)-8-benzyloxy-9-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-2,3,4,7,8,9-hexahydro-oxonin-2-ylmethyl ester 
• 876288-86-7 C₇₂H₁₀₀Br₂O₁₁Si₂ 
• 876288-66-3 2-(2-{3-[8-benzyloxy-9-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-2,3,4,7,8,9-hexahydro-oxonin-2-ylmethyl]-2-methyl-oxiranyl}-2-triethylsilanyloxy-ethyl)-7-(4-bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-5-methyl-oxocan-3-ol 
• 876288-87-8 C₆₄H₉₂Br₂O₁₀Si₂ 
• 876288-85-6 1-{3-[8-benzyloxy-9-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-2,3,4,7,8,9-hexahydro-oxonin-2-ylmethyl]-2-methyl-oxiranyl}-2-[7-(4-bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-yl]-ethanol 
• 876288-88-9 C₆₄H₉₀Br₂O₁₀Si₂ 
• 876288-83-4 5-[8-benzyloxy-9-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-2,3,4,7,8,9-hexahydro-oxonin-2-yl]-1-[7-(4-bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-yl]-3-methyl-pent-3-en-2-ol 
• 876288-84-5 5-[8-benzyloxy-9-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-2,3,4,7,8,9-hexahydro-oxonin-2-yl]-1-[7-(4-bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-yl]-3-methyl-pent-3-en-2-ol 
• 876288-89-0 2-[8-benzyloxy-9-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-2,3,4,7,8,9-hexahydro-oxonin-2-yl]-1-[7-(4-bromo-benzyloxy)-6-(4-bromo-benzyloxymethyl)-3-hydroxy-2,9-dimethyl-decahydro-1,5-dioxa-benzocycloocten-2-yl]-ethanone 
• 876288-81-2 (2R,3S,5Z,8R,9S)-[8-benzyloxy-9-benzyloxymethyl-3-(tret-butyldimethylsilyloxy)-2,3,4,7,8,9-hexahydrooxonin-2-yl]methyl trifluoromethanesulfonate 
• 876288-68-5 (2R,3S,5Z,8R,9S,2'E)-3-benzyloxy-2-benzyloxymethyl-8-(tret-butyldimethylsilyloxy)-9-(3'-iodo-but-2'-ynyl)-2,3,4,7,8,9-hexahydrooxonin 
• 876288-82-3 (2R,3S,5Z,8R,9S)-3-benzyloxy-2-benzyloxymethyl-8-(tret-butyldimethylsilyloxy)-9-(but-2'-ynyl)-2,3,4,7,8,9-hexahydrooxonin 
• 876288-80-1 [(Z)-(2R,3S,8R,9S)-8-Benzyloxy-9-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-2,3,4,7,8,9-hexahydro-oxonin-2-yl]-methanol 

Relevant academic research and scientific papers

Synthesis of the common FGHI-ring part of ciguatoxins

The common FGHI-ring part (2) of ciguatoxins has been synthesized from the F- and I-ring parts (6 and 5, respectively). The Nozaki-Hiyama-Kishi coupling of 6 with 5 followed by regio- and stereoselective epoxidation at C29 and C30 afforded an epoxide (4),