876522-38-2Relevant academic research and scientific papers
Nickel-Catalyzed N -Arylation of Amides with (Hetero)aryl Electrophiles by Using a DBU/NaTFA Dual-Base System
Lundrigan, Travis,Tassone, Joseph P.,Stradiotto, Mark
supporting information, p. 1665 - 1669 (2021/01/25)
The first nickel-catalyzed N -arylation of amides with (hetero)aryl (pseudo)halides employing an organic amine base is described. By using a bis(cyclooctadienyl)nickel/8-[2-(dicyclohexylphosphinyl)phenyl]-1,3,5,7-tetramethyl-2,4,6-trioxa-8-phosphaadamantane catalyst mixture in combination with DBU/NaTFA as a dual-base system, a diversity of (hetero)aryl chloride, bromide, tosylate, and mesylate electrophiles were successfully cross-coupled with structurally diverse primary amides, as well as a selection of secondary amide, lactam, and oxazolidone nucleophiles.
Nickel-Catalyzed N-Arylation of Primary Amides and Lactams with Activated (Hetero)aryl Electrophiles
Lavoie, Christopher M.,MacQueen, Preston M.,Stradiotto, Mark
, p. 18752 - 18755 (2016/12/26)
The first nickel-catalyzed N-arylation of amides with (hetero)aryl (pseudo)halides is reported, enabled by use of the air-stable pre-catalyst (PAd-DalPhos)Ni(o-tolyl)Cl (C1). A range of structurally diverse primary amides and lactams were cross-coupled successfully with activated (hetero)aryl chloride, bromide, triflate, tosylate, mesylate, and sulfamate electrophiles.
Direct synthesis of primary arylamines via C-N cross-coupling of aryl bromides and triflates with amides
Romero,Harrak,Basset,Orúe,Pujol
experimental part, p. 1951 - 1956 (2009/07/11)
Aryl halides and triflates are coupled with primary amides to give the corresponding arylamines in the presence of a palladium catalyst, a suitable ligand, and a base. The catalyst system performs well for a large number of different substrates at 100-150 °C without solvent, and with low catalyst levels (0.12 mol % Pd). Nicotinamide might be useful as a nitrogen source in the Pd-catalyzed amination reaction.
Pyridinium cationic-dimer antimalarials, unlike chloroquine, act selectively between the schizont stage and the ring stage of Plasmodium falciparum
Yoshikawa, Mai,Motoshima, Kazunori,Fujimoto, Kanji,Tai, Akihiro,Kakuta, Hiroki,Sasaki, Kenji
, p. 6027 - 6033 (2008/12/22)
Malaria is a leading cause of death in developing countries, and the emergence of strains resistant to the main therapeutic agent, chloroquine, has become a serious problem. We have developed cationic-dimer type antimalarials, MAP-610 and PMAP-H10, which
