87671-67-8

Upstream product

• 133437-34-0 2-allylamino-4'-methyldiphenyl ether 
• 133437-35-1 2-benzylamino-4'-methyldiphenyl ether 
• 87671-57-6 2,2-diethoxy-2,3-dihydro-2-phenyl-3-p-tolyl-1,3,2-benzoxazaphosph(V)ole 
• 58656-56-7 2,3-dihydro-2,2-dimethoxy-2-phenyl-3-p-tolyl-1,3,2-benzoxazaphosph(V)ole 
• 20927-98-4 2-p-tolyloxy-aniline 
• 624-31-7 4-tolyl iodide 
• 95-55-6 2-amino-phenol 
• 106-38-7 para-bromotoluene 
• 64-19-7 acetic acid 
• 106-49-0 p-toluidine 
• 599-86-0 4-methyl-N-(4-methylphenyl)benzenesulfonamide 
• 585526-04-1 N-(4-methoxy-4-methylcyclohexa-2,5-dien-1-ylidene)-4-methylbenzenesulfonamide 
• 928642-45-9 6-diazo-2-cyclohexen-1-one 
• 273-53-0 benzoxazole 

Downstream Products

• 107455-62-9 N-(2-methoxyphenyl)-4-methylaniline 

Relevant academic research and scientific papers

COMPOUND WHICH INHIBITS TELOMERE-BINDING PROTEIN, AND TELOMERE-BINDING PROTEIN INHIBITOR CONTAINING SAME

The compound according to the present invention is a compound represented by the following chemical formula: wherein, in the above-described chemical formula, R1 is oxygen or sulfur, and R2 to R6 are each independently sel

Ligand-Free, Cu- and Fe-Catalyzed Selective Ring-Opening Arylations of Benzoxazoles with Aryl Iodides

Cu- or Fe-based catalyst systems have been reported to selectively catalyze the N,N-diarylation or N-monoarylation of benzoxazoles ring-opening with aryl iodides in the absence of additional added ligand in polyethylene glycol under an inert atmosphere. Two types of coupling products (triphenylamines and diphenylamines) have been examined and the reaction routes can be simply controlled by changing the metal salts (Cu or Fe) as catalyst. A range of substrates have been investigated for the diverse reactions, and the corresponding arylation products were achieved in good to high yields. This selective, low-cost, and environmentally friendly protocol displays great potential for replacing existing methodologies as well as extending the synthetic applications of benzoxazoles.

A method of synthesis of natural product Glycozolicine

The invention discloses a method for synthesizing a natural product Glycozolicine, and belongs to the field of organic synthesis. The method comprises the following steps: catalyzing the reaction of 6-diazo-2-cyclohexene-1-ketone and paratoluidine by usin

Copper-catalyzed N=H insertion and oxidative aromatization cascade: Facile synthesis of 2-arylaminophenols

A copper-catalyzed cascade reaction of N-H insertion and oxidative aromatization has been developed. 2-Arylaminophenols have been prepared in moderate to high yields from the diazo substrates. Moreover, this newly established methodology allows efficient access to natural 1-oxygenated carbazole alkaloids, such as glycozolicine and murrayafoline A. Copper falls: A copper-catalyzed cascade reaction of N=H insertion and oxidative aromatization yields 2-arylaminophenols. This newly established methodology also allows efficient access to natural 1-oxygenated carbazole alkaloids, such as glycozolicine and murrayafoline A.

One-pot synthesis of diarylamines from two aromatic amines via oxidative dearomatization-imino exchange-reductive aromatization

A one-pot synthetic strategy for diarylamines using only aromatic amines as starting materials has been developed. This method involved a PhI(OAc) 2-induced oxidative dearomatization of N-sulfonyl protected para-substituted anilines, a Bi(OTf)3-catalyzed imino exchange reaction between N-sulfonyl cyclohexadienimines and aromatic amines, and a CF3COOH/Zn mediated reductive aromatization of the resulting N-aryl cyclohexadienimines.

Synthetic approach for constructing the 1-oxygenated carbazole core and its application to the preparation of natural alkaloids

An efficient synthetic approach for the construction of the 1-oxygenated carbazole core is described. The condensation of cyclohexane-1,2-diones with a series of anilines yielded the corresponding 2-anilinocyclohex-2-en-1-ones, followed by the one-pot aromatization/methylation process of the latter to provide N-aryl-2-methoxyanilines. A palladium(II)-catalyzed cyclization of these N-aryl-2-methoxyanilines afforded the desired 1-methoxycarbazole frame in high overall yields. This protocol was implemented for the total synthesis of the naturally occurring glycozolicine and 6-methoxymurrayanine.

Synthetic approach for constructing the 1-oxygenated carbazole core and its application to the preparation of natural alkaloids

An efficient synthetic approach for the construction of the 1-oxygenated carbazole core is described. The condensation of cyclohexane-1,2-diones with a series of anilines yielded the corresponding 2-anilinocyclohex-2-en-1-ones, followed by the one-pot aromatization/methylation process of the latter to provide N-aryl-2-methoxyanilines. A palladium(II)-catalyzed cyclization of these N-aryl-2-methoxyanilines afforded the desired 1-methoxycarbazole frame in high overall yields. This protocol was implemented for the total synthesis of the naturally occurring glycozolicine and 6-methoxymurrayanine. Georg Thieme Verlag Stuttgart · New York.

Copper-catalyzed direct synthesis of di- and triphenylamines: A dramatic accelerating effect of 2-aminophenols

Utilizing the dramatic accelerating effect of 2-aminophenols, we developed a copper-catalyzed system for the selective synthesis of di- and triphenylamines. In addition, N- and O-arylation could be achieved in coupling reactions between 2-aminophenol and nitroaryl halides. A copper-catalyzed system for the selective synthesis of di- and triphenylamines has been developed. This new protocol provides a direct and efficient way to synthesize o-hydroxy-substituted di- and triphenylamines. Copyright

Orthogonal Cu- and Pd-based catalyst systems for the O- and N-arylation of aminophenols

O- or N-arylated aminophenol products constitute a common structural motif in various potentially useful therapeutic agents and/or drug candidates. We have developed a complementary set of Cu- and Pd-based catalyst systems for the selective O- and N-arylation of unprotected aminophenols using aryl halides. Selective O-arylation of 3- and 4-aminophenols is achieved with copper-catalyzed methods employing picolinic acid or CyDMEDA, trans-N,N′-dimethyl-1,2- cyclohexanediamine, respectively, as the ligand. The selective formation of N-arylated products of 3- and 4-aminophenols can be obtained with BrettPhos precatalyst, a biarylmonophosphine-based palladium catalyst. 2-Aminophenol can be selectively N-arylated with CuI, although no system for the selective O-arylation could be found. Coupling partners with diverse electronic properties and a variety of functional groups can be selectively transformed under these conditions.

Production of keto acids

A method for the production of a keto acid having the general formula STR1 wherein R1 and R2 independently represent a straight or branched chain alkyl of 1-18 carbon atoms, a cycloalkyl of 4-8 carbon atoms or a phenyl, each of which may be substituted by at least one substituent selected from the group consisting of halogen atoms and alkyls having 1-4 carbon atoms, an aralkyl of 7-10 carbon atoms, alkoxyalkyl having 2-20 carbon atoms, tetrahydrofuryl alkyl, alkylcarboxy alkyl, alkylcarboxy benzyl, or R1 and R2 together with the adjacent nitrogen atom may form a heterocyclic ring, or one of R1 and R2 is hydrogen, but R1 and R2 may not simultaneously be methyl or ethyl or benzyl which comprises reacting a m-amino phenol having the general formula STR2 wherein R1 and R2 are the same as above, with phthalic anhydride, in an organic solvent in an amount of less than 0.5 parts by weight per part of m-amino phenol.