87676-93-5

Basic information

• Product Name: alpha-(2-Fluorophenyl)-alpha-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol
• Synonyms: Impact sopra
• CAS NO: 87676-93-5
• Molecular Formula: C16H24F2N2O
• Molecular Weight: 301.29
• Mol File: 87676-93-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 506.5 °C at 760 mmHg
• Flash Point: 260.1 °C
• Appearance: /
• Density: 1.29 g/cm³
• Vapor Pressure: 4.43E-11mmHg at 25°C
• Refractive Index: 1.6
• CAS DataBase Reference: alpha-(2-Fluorophenyl)-alpha-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: alpha-(2-Fluorophenyl)-alpha-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol(87676-93-5)
• EPA Substance Registry System: alpha-(2-Fluorophenyl)-alpha-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol(87676-93-5)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R22:
• Safety Statements: S22:; S24/25:
• Hazardous Substances Data: 87676-93-5(Hazardous Substances Data)

Usage

General Description

Alpha-(2-Fluorophenyl)-alpha-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol is a chemical compound with potential biological and pharmacological properties. It is a triazole derivative that contains two fluoro-substituted phenyl groups and an ethanolic moiety. alpha-(2-Fluorophenyl)-alpha-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol has been studied for its potential as an antifungal, antitumor, and anticonvulsant agent. It may also have potential applications in the fields of medicine and agriculture. Further research is necessary to fully understand the properties and potential uses of this chemical.

InChI:InChI=1/C16H13F2N3O/c17-13-7-5-12(6-8-13)16(22,9-21-11-19-10-20-21)14-3-1-2-4-15(14)18/h1-8,10-11,22H,9H2

Upstream product

• 342-25-6 2,4'-difluorobenzophenone 
• 288-88-0 1,2,4-Triazole 
• 88374-05-4 1-(2-fluorophenyl)-1-(4-fluorophenyl)ethylene oxide 
• 76674-21-0 flutriafol 
• 1765-93-1 4-fluoroboronic acid 
• 1813-93-0 ethyl 2-(2-fluorophenyl)-2-oxoacetate 
• 1053246-13-1 (S)-2-(2-fluorophenyl)-2-(4-fluorophenyl)oxirane 

Relevant articles and documents

Preparation of a novel bridged bis(β-cyclodextrin) chiral stationary phase by thiol-ene click chemistry for enhanced enantioseparation in HPLC

A bridged bis(β-cyclodextrin) ligand was firstly synthesized via a thiol-ene click chemistry reaction between allyl-ureido-β-cyclodextrin and 4-4′-thiobisthiophenol, which was then bonded onto a 5 μm spherical silica gel to obtain a novel bridged bis(β-cyclodextrin) chiral stationary phase (HTCDP). The structures of HTCDP and the bridged bis(β-cyclodextrin) ligand were characterized by the 1H nuclear magnetic resonance (1H NMR), solid state 13C nuclear magnetic resonance (13C NMR) spectra spectrum, scanning electron microscope, elemental analysis, mass spectrometry, infrared spectrometry and thermogravimetric analysis. The performance of HTCDP in enantioseparation was systematically examined by separating 21 chiral compounds, including 8 flavanones, 8 triazole pesticides and 5 other common chiral drugs (benzoin, praziquantel, 1-1′-bi-2-naphthol, Tr?ger's base and bicalutamide) in the reversed-phase chromatographic mode. By optimizing the chromatographic conditions such as formic acid content, mobile phase composition, pH values and column temperature, 19 analytes were completely separated with high resolution (1.50-4.48), in which the enantiomeric resolution of silymarin, 4-hydroxyflavanone, 2-hydroxyflavanone and flavanone were up to 4.34, 4.48, 3.89 and 3.06 within 35 min, respectively. Compared to the native β-CD chiral stationary phase (CDCSP), HTCDP had superior enantiomer separation and chiral recognition abilities. For example, HTCDP completely separated 5 other common chiral drugs, 2 flavanones and 3 triazole pesticides that CDCSP failed to separate. Unlike CDCSP, which has a small cavity (0.65 nm), the two cavities in HTCDP joined by the aryl connector could synergistically accommodate relatively bulky chiral analytes. Thus, HTCDP may have a broader prospect in enantiomeric separation, analysis and detection. This journal is

Continuous preparation method of flutriafol

The invention relates to a continuous preparation method of flutriafol. 1,2,4-triazole and 1-(2-fluorophenyl)-1-(4-fluorophenyl) ethylene oxide react in a microchannel continuous flow reactor in the presence of an organic solvent and a soluble alkali to obtain the flutriafol. The method is short in reaction time and high in automatic production level, promotes the competitiveness of an enterprise,is small in safety hazard in the process of synthesizing the target product, reduces the risk coefficient, is high in yield of the target product, simple in post treatment and little in solid waste,and realizes a cleaner and environment-friendly production process.

Efficient and Enantioselective Rhodium(I)-Catalyzed Arylation of α-Ketoesters: Synthesis of (S)-Flutriafol

An enantioselective addition of arylboronic acids and α-ketoesters promoted by a Rhodium(I)-chiral diene catalyst is reported. The transformation proceeds regioselectively in the presence of as low as 0.5 mol% of the catalyst generated in situ from a Rhod