342-25-6

Basic information

• Product Name: 2,4'-Difluorobenzophenone
• Synonyms: LABOTEST-BB LT00159745;2,4"-DIFLUEOROBENZOPHENONE;2,4''-FLUOROBENZOPHENONE;2,4'-Difluorobenzophenone;(2-fluorophenyl)(4-fluorophenyl)methanone;2',4-Difluorobenzophenone;Methanone, (2-fluorophenyl)(4-fluorophenyl)-;2-Fluorophenyl(4-fluorophenyl) ketone
• CAS NO: 342-25-6
• Molecular Formula: C₁₃H₈F₂O
• Molecular Weight: 218.2
• EINECS: 206-441-7
• Product Categories: Acetophenone Series;Aromatic Benzophenones & Derivatives (substituted);Benzophenones (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer Research
• Mol File: 342-25-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 22-24 °C(lit.)
• Boiling Point: 176-178 °C16 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: clear light yellow liquid after melting
• Density: 1.244 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.5689(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform, Methanol
• BRN: 3268520
• CAS DataBase Reference: 2,4'-Difluorobenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4'-Difluorobenzophenone(342-25-6)
• EPA Substance Registry System: 2,4'-Difluorobenzophenone(342-25-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36/38
• Safety Statements: 26-37/39-24/25-37-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 342-25-6(Hazardous Substances Data)

Usage

Chemical Properties

clear light yellow liquid after melting

Uses

2,4’-Difluorobenzophenone is a reactant in the synthesis of EP1 receptor antagonists for the treatment of overactive bladder. Also used in the design and synthesis of thiosemicarbazone cathespin L inhibitors.

Upstream product

• 462-06-6 fluorobenzene 
• 393-52-2 2-Fluorobenzoyl chloride 
• 56-23-5 tetrachloromethane 
• 1765-93-1 4-fluoroboronic acid 
• 446-52-6 2-Fluorobenzaldehyde 
• 403-43-0 4-fluorobenzoyl chloride 
• 7613-38-9 1,1,1-trichloro-2-(2-fluoro-phenyl)-2-(4-fluoro-phenyl)-ethane 
• 352-13-6 4-flourophenylmagnesium bromide 

Downstream Products

• 88374-05-4 1-(2-fluorophenyl)-1-(4-fluorophenyl)ethylene oxide 
• 76674-21-0 flutriafol 
• 1204771-21-0 C₁₇H₁₀FN₃O₂S 
• 2839-50-1 3-fluoroxanthone 
• 1428244-96-5 ?(4-fluoro-2-hydroxyphenyl)(2-fluorophenyl)methanone 
• 1428244-97-6 (2-fluoro-6-hydroxyphenyl)(4-fluorophenyl)methanone 
• 1428244-98-7 (4-fluoro-2-hydroxyphenyl)(2-fluoro-6-hydroxyphenyl)methanone 
• 1370037-15-2 diethyl (hydroxy)(2-fluorophenyl)(4-fluorophenyl)methylphosphonate 
• 1242146-61-7 [Co(2-(4-FC₆H₃)C(=O)(2'-FC₆H₄))(PMe₃)3] 
• 1220124-34-4 [(4-fluorophenyl)-(2-fluorophenyl)ketone]thiosemicarbazone 
• 128092-72-8 (2-fluorophenyl)-(4-fluorophenyl)phenylmethanol 
• 566885-58-3 bis(4-fluorophenyl)-2-fluorophenylmethanol 
• 153877-53-3 (2-fluorophenyl)(4-fluorophenyl)methanol 
• 106147-66-4 4(5)-<<2-(2-fluorophenyl)-2-(4'-fluorophenyl)>-ethyl>-imidazole 

Relevant articles and documents

Method of utilizing continuous flow microreactor to synthesize benzophenone derivative

The invention belongs to the technical field of organic synthesis, and particularly relates to a method of utilizing a continuous flow microreactor to synthesize a benzophenone derivative. The methodincludes: using aryl Grignard reagent and acyl chloride as raw materials; at normal temperature, continuously synthesizing the benzophenone derivative in the microreactor; recycling a reaction solvent2-methyl tetrahydrofuran. Problems of environmental pollution and reaction operation safety caused by the fact that conventional Fridel-Crafts reaction is excessively dependent on reagents like aluminum trichloride, ferric trichloride and zinc dichloride are avoided, the defect that novel catalytic processes are expensive in catalytic reagent and harsh in operation condition is made up, and continuous synthesis of a medical intermediate ketoprofen nitrile is realized efficiently. The method has the advantages of high operation convenience, high reaction safety, high yield, high efficiency andreaction solvent reusability and is environment-friendly and efficient.

A novel Br?nsted acid catalyst for Friedel-Crafts acylation

Bis(trifluoroalkylsulfonylimino)trifluoromethanesulfonic acid has demonstrated remarkable catalytic ability in the electrophilic acylation of aromatic substrates. Various perfluoroalkyl substituted aroyl chlorides are employed in Friedel-Crafts acylation typically using 1 mol % of catalyst. Crown Copyright

Influence of isomerism of difluorobenzophenone on the synthesis and properties of poly(arylene ether ketones)

The influence of isomerism of difluorobenzophenone on the efficiency of polycondensation and the properties of homo-and copoly(arylene ether ketones) was studied. The latter were prepared by the reaction of 2,4'-and 4,4'-difluorobenzophenone with potassium diphenolates of bisphenol A and phenolphthalein in N,N-dimethylacetamide. A high content of an admixture of the 2,4'-isomer in 4,4'-difluorobenzophenone decreases the molecular weight of related poly(arylene ether ketones) and has no substantial effect on their glass transition temperature.