342-25-6

Usage

Uses

Used in Pharmaceutical Industry:
2,4'-Difluorobenzophenone is used as a reactant for the synthesis of EP1 receptor antagonists, which are crucial in the treatment of overactive bladder. Its unique structure allows for the development of targeted therapies that can alleviate symptoms and improve the quality of life for patients suffering from this condition.
Additionally, 2,4'-Difluorobenzophenone is utilized in the design and synthesis of thiosemicarbazone cathepsin L inhibitors. These inhibitors play a significant role in the development of novel therapeutic strategies for various diseases, including cancer, by targeting specific enzymes involved in their progression.

Upstream product

• 352-13-6 4-flourophenylmagnesium bromide 
• 393-52-2 2-Fluorobenzoyl chloride 
• 462-06-6 fluorobenzene 
• 7613-38-9 1,1,1-trichloro-2-(2-fluoro-phenyl)-2-(4-fluoro-phenyl)-ethane 
• 56-23-5 tetrachloromethane 
• 403-43-0 4-fluorobenzoyl chloride 
• 1765-93-1 4-fluoroboronic acid 
• 446-52-6 2-Fluorobenzaldehyde 

Downstream Products

• 132287-51-5 2,4'-difluorodiphenylmethane 
• 106147-66-4 4(5)-<<2-(2-fluorophenyl)-2-(4'-fluorophenyl)>-ethyl>-imidazole 
• 153877-53-3 (2-fluorophenyl)(4-fluorophenyl)methanol 
• 128092-72-8 (2-fluorophenyl)-(4-fluorophenyl)phenylmethanol 
• 566885-58-3 bis(4-fluorophenyl)-2-fluorophenylmethanol 
• 1220124-34-4 [(4-fluorophenyl)-(2-fluorophenyl)ketone]thiosemicarbazone 
• 1242146-61-7 [Co(2-(4-FC₆H₃)C(=O)(2'-FC₆H₄))(PMe₃)3] 
• 1370037-15-2 diethyl (hydroxy)(2-fluorophenyl)(4-fluorophenyl)methylphosphonate 
• 1428244-96-5 ?(4-fluoro-2-hydroxyphenyl)(2-fluorophenyl)methanone 
• 1428244-97-6 (2-fluoro-6-hydroxyphenyl)(4-fluorophenyl)methanone 
• 1428244-98-7 (4-fluoro-2-hydroxyphenyl)(2-fluoro-6-hydroxyphenyl)methanone 
• 2839-50-1 3-fluoroxanthone 
• 1204771-21-0 C₁₇H₁₀FN₃O₂S 
• 88374-05-4 1-(2-fluorophenyl)-1-(4-fluorophenyl)ethylene oxide 

Relevant academic research and scientific papers

Method of utilizing continuous flow microreactor to synthesize benzophenone derivative

The invention belongs to the technical field of organic synthesis, and particularly relates to a method of utilizing a continuous flow microreactor to synthesize a benzophenone derivative. The methodincludes: using aryl Grignard reagent and acyl chloride as raw materials; at normal temperature, continuously synthesizing the benzophenone derivative in the microreactor; recycling a reaction solvent2-methyl tetrahydrofuran. Problems of environmental pollution and reaction operation safety caused by the fact that conventional Fridel-Crafts reaction is excessively dependent on reagents like aluminum trichloride, ferric trichloride and zinc dichloride are avoided, the defect that novel catalytic processes are expensive in catalytic reagent and harsh in operation condition is made up, and continuous synthesis of a medical intermediate ketoprofen nitrile is realized efficiently. The method has the advantages of high operation convenience, high reaction safety, high yield, high efficiency andreaction solvent reusability and is environment-friendly and efficient.

A method for preparing intermediate and its flutriafol

The invention relates to a flutriafol intermediate and a method for preparing the flutriafol intermediate and analogues thereof. The flutriafol intermediate is 2,4'-difluoro diphenylmethanone. The method comprises the following step of carrying out a coupled reaction for fluorobenzaldehyde and analogues thereof and 4-fluorophenylboronic acid and analogues thereof in a solventunder under the presence of a transition metal catalyst and under alkaline conditions to generate the flutriafol intermediate and the analogues thereof. The solvent is a mixed solvent of an organic solvent and water. The method is a new path for synthesizing the flutriafol intermediate and the analogues thereof. The method has the advantages of simple process, low cost and low three wastes, the transition metal catalyst can be repeatedly used, the content and yield of target products are relatively high, and the method is suitable for industrial production.

A novel Br?nsted acid catalyst for Friedel-Crafts acylation

Bis(trifluoroalkylsulfonylimino)trifluoromethanesulfonic acid has demonstrated remarkable catalytic ability in the electrophilic acylation of aromatic substrates. Various perfluoroalkyl substituted aroyl chlorides are employed in Friedel-Crafts acylation typically using 1 mol % of catalyst. Crown Copyright

Metal bis{(trifluoromethyl)sulfonyl}amide complexes: Highly efficient Friedel-Crafts acylation catalysts

A range of metal bis{(trifluoromethyl)sulfonyl}amide complexes, including many unreported ones, have been synthesised, most of which have been found to be excellent Friedel-Crafts acylation catalysts in the absence of solvent; these reactions have also been carried out in ionic liquids, which allow the catalysts to be recycled and reused.

Influence of isomerism of difluorobenzophenone on the synthesis and properties of poly(arylene ether ketones)

The influence of isomerism of difluorobenzophenone on the efficiency of polycondensation and the properties of homo-and copoly(arylene ether ketones) was studied. The latter were prepared by the reaction of 2,4'-and 4,4'-difluorobenzophenone with potassium diphenolates of bisphenol A and phenolphthalein in N,N-dimethylacetamide. A high content of an admixture of the 2,4'-isomer in 4,4'-difluorobenzophenone decreases the molecular weight of related poly(arylene ether ketones) and has no substantial effect on their glass transition temperature.

Preparation process of fluorine substituted aromatic compound

A preparation process of a fluorine substituted aromatic compound comprising reacting an alkali metal or alkali earth metal salt of an aromatic compound having a hydroxy group with an organic fluorinating agent is disclosed. As a representative fluorinating agent, a bis-dialkylamino-difluoromethane compound, for example, 2,2′-difluoro-1,3-dimethylimidazolidine, is exemplified. According to the process, an industrially useful fluorinated aromatic compound, for example, a fluorobenzene, a fluorine substituted benzophenone, a fluorine substituted diarylsulfone can be prepared with ease in economy without specific equipment.

Halophenylethylenes

These compounds have the general formula: STR1 wherein R and R1, which may be the same or different, are hydrogen or alkyl, preferably C1 -C4 alkyl, and X, Y and Z are each independently hydrogen, chlorine or fluorine, provided that when R, R1 and Z are hydrogen, X and Y are not both hydrogen or both fluorine, and are prepared by dehydrating an alcohol of the formula: STR2 by, for example, heating the alcohol in the presence of a catalytic amount of a strong acid such as p-toluenesulphonic acid and preferably in the presence of an inert solvent. The compounds are intermediate for the preparation of fungicidal compounds.

Process for the preparation of phenyl ketones

A process for the preparation of phenyl ketones, characterized in that, in a first stage, a halo- or trihalomethylbenzene is reacted with a trihalomethylated aliphatic or aromatic compound in the presence of boron trifluoride in an amount such that the absolute pressure of boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent, and in that, in a second stage, the resultant product is hydrolyzed. The products are used as intermediates in the synthesis of compounds having a pharmaceutical or phytosanitary (e.g., herbicidal) activity.