877-53-2

Basic information

• Product Name: 2,4-dimethylphenyl acetate
• Synonyms: 2,4-Dimethylphenyl acetate; Phenol, 2,4-dimethyl-, acetate
• CAS NO: 877-53-2
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2011
• Mol File: 877-53-2.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 226.4°C at 760 mmHg
• Flash Point: 89.2°C
• Density: 1.028g/cm³
• Vapor Pressure: 0.0821mmHg at 25°C
• Refractive Index: 1.503
• CAS DataBase Reference: 2,4-dimethylphenyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dimethylphenyl acetate(877-53-2)
• EPA Substance Registry System: 2,4-dimethylphenyl acetate(877-53-2)

Safety Data

• Hazardous Substances Data: 877-53-2(Hazardous Substances Data)

Usage

General Description

2,4-dimethylphenyl acetate is a chemical compound that is derived from acetic acid and 2,4-dimethylphenol. It is commonly used as a fragrance ingredient in various cosmetic and personal care products. 2,4-dimethylphenyl acetate has a sweet, floral, and slightly fruity odor which makes it a popular choice for perfumes, lotions, and soaps. In addition to its use in the fragrance industry, 2,4-dimethylphenyl acetate also has applications in the production of dyes and pigments. 2,4-dimethylphenyl acetate is known to be relatively stable and non-reactive under normal conditions, making it a safe and reliable choice for a variety of commercial products.

Upstream product

• 106-42-3 para-xylene 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 108-38-3 m-xylene 
• 75-36-5 acetyl chloride 
• 105-67-9 2,4-Xylenol 
• 3240-34-4 [bis(acetoxy)iodo]benzene 

Downstream Products

• 1198-66-9 3,5-dimethyl-2-hydroxyacetophenone 
• 105-67-9 2,4-Xylenol 
• 55004-76-7 4-hydroxy-6,8-dimethylcoumarin 
• 1459244-00-8 C₁₁H₁₁F₃O₄S 
• 90743-02-5 2-hydroxy-3,6-dimethylacetophenone 

Relevant articles and documents

Direct Acetoxylation of Arenes

Acetoxylation of arenes is an important reaction and an unmet need in chemistry. We report a metal-free, direct acetoxylation reaction using sodium nitrate under an anhydrous environment of trifluoroacetic acid, acetic acid, and acetic anhydride. Arenes (31 examples), with oxidation potentials (Eox, in V vs SCE) lower than benzene (2.48 V), were acetoxylated with good yields and regioselectivity. A stepwise, single electron-transfer mechanism is proposed.

Synthesis and anti-inflammatory activity of 2-oxo-2H-chromenyl and 2H-chromenyl-5-oxo-2,5-dihydrofuran-3-carboxylates

Cycloaddition reaction of 4-chloro-2-oxo-2H-chromene-3-carbaldehydes (3a-g) and 4-chloro-2H-chromene-3-carbaldehydes (7a-h) with activated alkynes (4a-b) provided the 2-oxo-2H-chromenyl-5-oxo-2,5-dihydrofuran-3-carboxylates (5a-n) and 2H-chromenyl-5-oxo-2,5-dihydrofuran-3-carboxylates (8a-p). All the prepared compounds were screened for anti-inflammatory activity. In vitro anti-inflammatory activity data demonstrated that the compounds 5g, 5i, 5k-l and 8f are effective among the tested compounds against TNF-α (1.108 ± 0.002, 0.423 ± 0.022, 0.047 ± 0.001, 0.070 ± 0.002 and 0.142 ± 0.001 μM) in comparison with standard compound Prednisolone (0.033 ± 0.002 μM). Based on in vitro results, three compounds (5i, 5k and 8f) have been selected for in vivo experiments and these compounds are identified as better compounds with respect to anti-inflammatory activity in LPS induced mice model. Compound 5i was identified as potent and showed significant reduction in TNF-α and IL-6.

Acetylation of alcohols and phenols under solvent-free conditions using iron zirconium phosphate

Iron zirconium phosphate (ZPFe) nanoparticles were found to function as an efficient catalyst for the acetylation of a wide range of alcohols and phenols using acetic anhydride, generating good to excellent yields under solvent-free conditions. The steric and electronic properties of various substrates had a significant influence on the reaction conditions required to achieve the acetylation. The catalyst used in the current study was characterized by inductively coupled plasma-optical emission spectrometry, X-ray diffraction, N2 adsorption-desorption, scanning electron microscopy, and transmission electron microscopy. These analyses revealed that the interlayer distance in the catalyst increased from 7.5 to 9.3 ? when Fe3+ was intercalated between the layers, whereas the crystallinity of the material was reduced. This nanocatalyst could also be recovered and reused at least six times without any discernible decrease in its catalytic activity. This new method for the acetylation of alcohols and phenols has several important advantages, including mild and environmentally friendly reaction conditions, as well as good to excellent yields and a facile work-up.