877265-22-0Relevant academic research and scientific papers
Palladium-Catalyzed, Norbornene-Mediated, ortho-Amination ipso-Amidation: Sequential C-N Bond Formation
Whyte, Andrew,Olson, Maxwell E.,Lautens, Mark
, p. 345 - 348 (2018/01/27)
A palladium-catalyzed, norbornene-mediated ortho- and ipso-C-N bond-forming Catellani reaction is reported. This reaction proceeds through a sequential intermolecular amination followed by intramolecular cyclization of a tethered amide. The products, ortho-aminated dihydroquinolinones, were generated in moderate to good yields and are present in bioactive molecules. This work highlights the challenge of competing intra- vs intermolecular palladium-catalyzed processes.
A concise synthesis of 5-demethyl-HKI 0231A and 5-demethyl-HKI 0231B
Kraus, George A.,Wu, Tao
, p. 7801 - 7803 (2007/10/03)
The pentacyclic skeleton of HKI 0231A and HKI 0231B was synthesized by a novel radical cyclization/oxidation followed by DDQ oxidation to introduce the methoxyl groups. This is the first synthetic pathway to both the HKI 0231A and the HKI 0231B series.
